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Merck
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重要文件

H2292

Sigma-Aldrich

Histone H3.1 human

同義詞:

Histone, Human

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About This Item

CAS號碼:
分類程式碼代碼:
12352202
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

human

品質等級

重組細胞

expressed in E. coli

形狀

liquid

濃度

1 mg/mL

技術

MALDI-TOF: suitable

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... H3C1(8350)

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一般說明

Histone H3.1 is a histone H3 variant.[1] It differs from H3.2 with residue 96 being a cysteine instead of serine.[2] H3.1 is a replication-dependent histone and is a component of nucleosomes during the S-phase.[3]

應用

Histone H3.1 human has been used in in vitro Schizosaccharomyces pombe Set7 histone methyltransferase assay for matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) studies.[4]

生化/生理作用

Histone H3.1 human (H3.1) undergoes a majority of post-translational modification especially acetylation and demethylation in lysine 14 and 9 respectively.[1] During differentiation, the levels of H3.1 transcripts decrease as cell division slows down.[2] The incorporation of H3.1 into chromatin is mediated by a chaperone, chromatin assembly factor (CAF-1).[1] A transversion mutation in the H3.1 may be implicated in glioma.[3]

外觀

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Sandra B Hake et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(17), 6428-6435 (2006-03-31)
In the history of science, provocative but, at times, controversial ideas have been put forward to explain basic problems that confront and intrigue the scientific community. These hypotheses, although often not correct in every detail, lead to increased discussion that
Gang Wu et al.
Nature genetics, 44(3), 251-253 (2012-01-31)
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found
Yunpeng Shen et al.
Structure (London, England : 1993), 27(4), 631-638 (2019-02-19)
Histone methylation by histone methyltransferases (HMTases) has a key role in transcriptional regulation. Discrepancies between the known HMTases and the histone lysine methylome suggest that HMTases remain to be identified. Here we report the discovery, characterization, and crystal structure of
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3

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