H0417

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

• 同義詞: HCF2, HCII, SERPIND1
• CAS號碼: 81604-65-1
• MDL號碼: MFCD00285907
• 分類程式碼代碼: 12352202
• NACRES: NA.61

屬性

• 生物源: human plasma
• 品質等級: 200
• 化驗: ≥90% (SDS-PAGE)
• 形狀: aqueous glycerol solution
• 分子量: ~66 kDa; ~66 kDa
• NCBI登錄號: NP_000176
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... SERPIND1(3053)

描述

生化／生理作用

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.

Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

單位定義

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

外觀

50% aqueous glycerol solution (vol/vol)

免責聲明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable