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G8397

Sigma-Aldrich

单唾液酸神经节苷酯GM2 来源于牛大脑

≥95% (TLC), lyophilized powder

同義詞:

神经节苷酯GM2，单唾液酸

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About This Item

CAS號碼:
19600-01-2
MDL號碼:
MFCD00131137
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

单唾液酸神经节苷酯GM2 来源于牛大脑, ≥95% (TLC)

品質等級

200

化驗

≥95% (TLC)

儲存溫度

−20°C

InChI

1S/C68H123N3O26/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-51(81)71-44(45(78)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-90-65-58(86)57(85)60(49(38-74)93-65)95-66-59(87)63(61(50(39-75)94-66)96-64-53(70-43(4)77)56(84)55(83)48(37-73)92-64)91-41-68(67(88)89)35-46(79)52(69-42(3)76)62(97-68)54(82)47(80)36-72/h31,33,44-50,52-66,72-75,78-80,82-87H,5-30,32,34-41H2,1-4H3,(H,69,76)(H,70,77)(H,71,81)(H,88,89)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,52+,53+,54+,55-,56+,57+,58+,59+,60+,61-,62+,63+,64-,65-,66-,68-/m1/s1

InChI 密鑰

USMMPBVNWHAJBE-YMEOXFOQSA-N

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相關類別

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc

一般說明

神经节苷脂GM2，一种属于鞘糖脂的单唾液酸神经节苷脂，主要分布于细胞质膜外叶。神经节苷脂是两亲性分子，含有不同糖基修饰的负电荷头基。不同种类的神经节苷脂的糖基各不相同。GM2主要在神经组织中表达。
神经节苷脂是神经元细胞膜和内质网的主要成分。 含有通过β糖苷键与神经酰胺连接的唾液酸多糖链。 有关神经节苷脂的分类，请参见Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980。

應用

单唾液酸神经节苷脂GM2（来源于牛大脑）可用于：
  • 在狗背根神经节(DRG)中研究添加GM2和去除所有细胞神经节苷脂对于神经突生长和神经元存活的影响
  • 作为高效薄层色谱法(HPTLC)参考标准品，并作为酶联免疫吸附试验(ELISA)抗原，分析人前列腺癌(CaP)细胞的神经节苷脂signatures
  • 作为GM1合酶体外活性测定反应液的组分

生化／生理作用

神经节苷脂GM2(GM2)是细胞膜的重要组分，对于细胞信号传导和代谢十分重要。多项研究表明，神经节苷脂参与癌症过程、呼肠孤病毒血清型1感染及胰岛素分泌和调节。在肿瘤细胞中，GM2参与细胞粘附、迁移和增殖，发挥保护作用。GM2表达下降代表严重的恶性肿瘤。GM2是呼肠孤病毒T1L(type 1 Lang)株的受体。神经系统相关的多种疾病中均发现GM2调节异常。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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K Nohara et al.
Breast cancer research and treatment, 48(2), 149-157 (1998-05-22)
Much evidence has shown that glycosphingolipids are involved in cellular recognition, regulation of cell growth, and metastasis. In the present study, the major glycosphingolipids of two widely studied human breast cancer cell lines were examined. The MCF-7 cell line has
H C Yohe et al.
Glycobiology, 7(8), 1215-1227 (1998-02-10)
Sialoglycosphingolipids (gangliosides) have been increasingly implicated as regulators of membrane signaling events. Macrophage ganglioside patterns dramatically increase in complexity when murine peritoneal macrophages are stimulated in vivo with the appearance of the sialidase-sensitive monosialoganglioside GM1b (cisGM1) as a major component.
M Sorice et al.
Bioscience reports, 19(3), 197-208 (1999-10-08)
In this study we analyzed by immunofluorescence, laser confocal microscopy, immunoelectron microscopy and label fracture technique the ganglioside distribution on the plasma membrane of several different cell types: human peripheral blood lymphocytes (PBL), Molt-4 lymphoid cells, and NIH 3T3 fibroblasts
Fengyi Liu et al.
International journal of biological sciences, 8(8), 1085-1096 (2012-09-20)
Insect β-N-acetyl-D-hexosaminidases with broad substrate-spectrum (IBS-Hex) are the homologues of human β-N-acetyl-D-hexosaminidase A/B (HsHex A/ B). These enzymes are distributed in most insect species and vary in physiological roles. In this study, the gene encoding an IBS-Hex, OfHEX2, was cloned
K Klisch et al.
Reproduction (Cambridge, England), 142(5), 667-674 (2011-09-08)
Spermatogonia are a potential source of adult pluripotent stem cells and can be used for testis germ cell transplantation. Markers for the isolation of these cells are of great importance for biomedical applications. Primordial germ cells and prepubertal spermatogonia in
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