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Merck
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重要文件

G5755

Sigma-Aldrich

Gly-Gly-Gly-Gly-Gly

同義詞:

Glycyl-glycyl-glycyl-glycyl-glycine, Pentaglycine

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About This Item

線性公式:
NH2CH2CO(NHCH2CO)3NHCH2COOH
CAS號碼:
分子量::
303.27
Beilstein:
1716946
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.26
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化驗

≥98% (TLC)

形狀

solid

顏色

white

應用

peptide synthesis

儲存溫度

−20°C

SMILES 字串

NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O

InChI

1S/C10H17N5O6/c11-1-6(16)12-2-7(17)13-3-8(18)14-4-9(19)15-5-10(20)21/h1-5,11H2,(H,12,16)(H,13,17)(H,14,18)(H,15,19)(H,20,21)

InChI 密鑰

MXHCPCSDRGLRER-UHFFFAOYSA-N

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生化/生理作用

Pentaglycine forms interpeptide bridges in peptidogylcan crosslinking and may be used as a tether for markers such as green fluorescent protein (GFP). Pentaglycine may be used as a model peptide in oligoglycine separation technology development.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Hiroshi Tomoda
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132(1), 37-44 (2012-01-05)
Methicillin-resistant Staphylococcus aureus (MRSA) is known as a major nosocomial pathogen that has also developed resistance to many antibiotics. Moreover, MRSA resistance to a last-resort antibiotic, vancomycin, has been reported. Therefore, new anti-infectious agents to prevent and treat MRSA infection
Aurelia Delaune et al.
PloS one, 6(2), e17054-e17054 (2011-03-10)
The WalKR two-component system is essential for viability of Staphylococcus aureus, a major pathogen. We have shown that WalKR acts as the master controller of peptidoglycan metabolism, yet none of the identified regulon genes explain its requirement for cell viability.
Alexander V Grishin et al.
Antibiotics (Basel, Switzerland), 9(12) (2020-12-23)
Antibacterial lysins are enzymes that hydrolyze bacterial peptidoglycan, which results in the rapid death of bacterial cells due to osmotic lysis. Lysostaphin is one of the most potent and well-studied lysins active against important nosocomial pathogen Staphylococcus aureus. Similarly to
Christof Renner et al.
Molecular cancer, 9, 2-2 (2010-01-08)
It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma. In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human
Steffen Wöll et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 136, 203-212 (2019-01-25)
Conventional chemotherapy is associated with therapy-limiting side effects, which might be alleviated by targeted chemotherapeutics such as immunoliposomes. The targeting ligands of immunoliposomes are commonly attached by unspecific chemical conjugation, bearing risk of structural heterogeneity and therewith related biological consequences.

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