推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 45 kDa
物種活性
human
包裝
antibody small pack of 25 μL
技術
microarray: suitable
western blot: 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GATA1(2623)
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一般說明
GATA is an important cis-element factor in the haematopoietic lineage belongs to GATA-binding protein family. It was first identified in the analysis of globin gene promoters and enhancers. There are different types of GATA proteins: GATA-1, GATA-2, GATA-3. It is expressed in erythroid, mast, megakaryocytic lineages, multipotential progenitor cells and lines.
GATA-1 (ERYF1, GF-1, NF-1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells.
免疫原
synthetic peptide corresponding to the C-terminal region of human GATA-1 (amino acids 394-413).
應用
Anti-GATA1 antibody produced in rabbit has been used in gel mobility shift assay and DNase I footprinting. It has also been used in confocal microscopy analysis.
生化／生理作用
GATA is a lineage-restricted transcription factor which plays a pivotal role in erythroid differentiation. It possesses potential binding sites in the regulatory sequences of all erythroid genes. GATA is expressed at higher levels during erythroid maturation. It is essential for terminal differentiation of erythrocytes and megakaryocytes and associated in vivo with the acetyl transferase p300/CBP. Mutation in GATA1 causes thrombocytopenia and abnormal platelet function.
GATA-binding factor 1 (GATA-1) is involved in blocking apoptosis of precursor cells and in controlling the balance between proliferation and cell cycle arrest.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
M E Cullen et al.
The Journal of biological chemistry, 272(4), 2464-2469 (1997-01-24)
We have set out to test a model for tissue-specific gene expression that relies on the early replication of expressed genes to sequester limiting activating transcription factors. Using an erythroid cell line, we have tested the changes in the DNA
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
Blobel GA, et al.
Proceedings of the National Academy of Sciences of the USA, 95(5), 2061-2066 (1998)
Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis
Kadri Z, et al.
Genes & Development, 29(24), 2603-2616 (2015)
GATA-binding transcription factors in hematopoietic cells.
S H Orkin
Blood, 80(3), 575-581 (1992-08-01)
Sascha C Hughan et al.
Blood, 105(11), 4369-4376 (2005-02-11)
Defects in the X-linked DNA-binding megakaryocyte transcription factor GATA1 cause thrombocytopenia and abnormal platelet function. However, detailed studies of GATA1 function in platelet activation are lacking. Here, we studied platelets from GATA1-deficient mice and from a male patient (S14) with
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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