F8304

黄酮哌酯 盐酸盐

≥98% (HPLC), solid

• 同義詞: 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040
• 經驗公式（希爾表示法）: C₂₄H₂₅NO₄ · HCl
• CAS號碼: 3717-88-2
• 分子量：: 427.92
• EC號碼: 223-066-4
• MDL號碼: MFCD00072099
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724484
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: white
• 溶解度: H₂O: ~6.6 mg/mL
• 起源: Johnson & Johnson
• SMILES 字串: Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4
• InChI: 1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
• InChI 密鑰: XOEVKNFZUQEERE-UHFFFAOYSA-N
• 基因資訊: human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622)

描述

生化／生理作用

Flavoxate, a flavone derivative and a tertiary-amine antimuscarinic possess antispasmodic properties. It is a strong smooth muscle relaxant that selectively acts on the pelvic region and is used in the symptomatic treatment of overactive bladder (OAB) and incontinence. Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues. It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder. Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.

L-type Ca²⁺ (Ca_v1.2) channel inhibitor

特點和優勢

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H335
• 防範說明: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• 危險分類: Acute Tox. 4 Oral - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves