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Merck
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重要文件

F6777

Sigma-Aldrich

氟卡尼 乙酸盐

≥98% (TLC), powder, sodium channel blocker

同義詞:

N -(2-哌啶基甲基)-2,5--(2,2,2-三氟乙氧基)苯甲酰胺 乙酸盐

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About This Item

經驗公式(希爾表示法):
C17H20F6N2O3 · C2H4O2
CAS號碼:
分子量::
474.39
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

氟卡尼 乙酸盐,

品質等級

起源

Medicis

儲存溫度

2-8°C

SMILES 字串

CC(O)=O.FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2

InChI

1S/C17H20F6N2O3.C2H4O2/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11;1-2(3)4/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26);1H3,(H,3,4)

InChI 密鑰

RKXNZRPQSOPPRN-UHFFFAOYSA-N

基因資訊

human ... SCN5A(6331)

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生化/生理作用

IC 类抗心律失常药;钠通道阻滞药

特點和優勢

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象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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P Somani
Clinical pharmacology and therapeutics, 27(4), 464-470 (1980-04-01)
A new class I antiarrhythmic, flecainide, was investigated in 10 patients to assess short-term efficacy and safety. All patients were hospitalized for 3 days; no antiarrhythmics were given on days 1 and 3. On day 2 flecainide 1 mg/kg was
Drug therapy. Flecainide.
D M Roden et al.
The New England journal of medicine, 315(1), 36-41 (1986-07-03)
P Maury et al.
Archives des maladies du coeur et des vaisseaux, 92(2), 273-277 (1999-03-17)
Poisoning with flecainide acetate is rare and associated with a high mortality. This usually occurs after massive ingestion but can also be observed during therapeutic overdose in patients with renal failure or with amiodarone therapy. The prognostic depends on the
Kosuke Doki et al.
Pharmacogenetics and genomics, 22(11), 777-783 (2012-09-04)
To investigate the association between age-related decline in flecainide clearance and CYP2D6 genotype, we conducted a population pharmacokinetic analysis of flecainide using routine therapeutic drug monitoring data. Population pharmacokinetic analysis was performed on retrospective data from 163 genotyped patients treated
J C Perry et al.
American heart journal, 124(6), 1614-1621 (1992-12-11)
A review of all published experience with flecainide in infants, children, and fetuses was performed to evaluate the appropriate place of the drug in pediatric practice and to determine dosing guidelines. A total of 704 case references was generated. Flecainide

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