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A8423

Sigma-Aldrich

盐酸胺碘酮 盐酸盐

≥98% (TLC), powder, ion channel blocker

同義詞:

2-丁基-3-苯并呋喃基-4-[2-(二乙氨基)乙氧基]-3,5-二碘苯基酮 盐酸盐, (2-丁基-3-苯并呋喃基) [4-[2-(二乙氨基)乙氧基]-3,5-二碘苯基] 甲酮 盐酸盐

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About This Item

經驗公式(希爾表示法):
C25H29I2NO3 · HCl
CAS號碼:
分子量::
681.77
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

盐酸胺碘酮 盐酸盐, ≥98%

化驗

≥98%

形狀

powder

起源

Wyeth

儲存溫度

2-8°C

SMILES 字串

C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl

InChI

1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

InChI 密鑰

ITPDYQOUSLNIHG-UHFFFAOYSA-N

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應用

盐酸胺碘酮是一种非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中,随后发生线粒体断裂和细胞死亡。 盐酸胺碘酮可用于废水处理厂废水中甲状腺破坏物质浓度测量研究。
盐酸胺碘酮用于研究其与半胱胺的相互作用,刺激培养的生物传感器细胞系发生自噬。也用于幼虫和成虫器官毒性基因组学筛选,分析药物的转录作用。

生化/生理作用

非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中,随后发生线粒体断裂和细胞死亡。

特點和優勢

该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里

基底

CYP2C8/9 和 CYP3A 家族(次要通路)抑制剂和底物;CYP2D6、CYP3A 家族、CYP2D6、CYP2A6、CYP2B6 去乙基形式抑制剂

訊號詞

Warning

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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