F3771

Fumonisin B₂ from Fusarium moniliforme

sphingosine N-acyltransferase inhibitor

• 同義詞: FB₂, Fumonisin B₂
• 經驗公式（希爾表示法）: C₃₄H₅₉NO₁₄
• CAS號碼: 116355-84-1
• 分子量：: 705.83
• MDL號碼: MFCD00133350
• 分類程式碼代碼: 12352202
• PubChem物質ID: 24894857
• NACRES: NA.77

屬性

• 生物源: Fusarium sp. (Fusarium moniliforme)
• 化驗: ≥96% (TLC)
• 形狀: powder
• 溶解度: methanol: 10 mg/mL, clear, colorless to faintly yellow
• 儲存溫度: −20°C
• SMILES 字串: CCCCC(C)C(OC(=O)CC(CC(O)=O)C(O)=O)C(CC(C)CCCCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(O)=O)C(O)=O
• InChI: 1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)
• InChI 密鑰: UXDPXZQHTDAXOZ-UHFFFAOYSA-N

描述

一般說明

Fumonisin B₂ (FB₂) is a diester of tricarballylic acid and polyhydric alcohols.[1]. Fumonisins B₂ (FB₂) does not have one or more hydroxyl groups at the C5 or C10 positions.[2]

Mycotoxin originally isolated from Fusarium sp, which grows on corn. Produces neural tube defects and craniofacial abnormalities in fetuses. Many strains of Aspergillus niger growing naturally on grapes are capable of producing fumonisin B₂, so it is now a concern for human consumption of grapes, raisins, and wine.

應用

Fumonisin B₂ (FB₂) from Fusarium moniliforme has been used:

• as a standard for the detection of FB₂ by high performance liquid chromatography (HPLC) in corn based food products[1][3]
• used as standard in the determination of fumonisin B1 and B2 in corn and corn-based products by high-performance liquid chromatography[3]
• as a standard in the determination of mycotoxins by HPLC[4]

生化／生理作用

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H351
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges