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Merck
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重要文件

F1293

Sigma-Aldrich

非那雄胺

≥98% (HPLC), powder

同義詞:

N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺

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選擇尺寸

100 MG


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選擇尺寸

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100 MG

About This Item

經驗公式(希爾表示法):
C23H36N2O2
CAS號碼:
分子量::
372.54
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.77


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化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: soluble >20 mg/mL

儲存溫度

room temp

SMILES 字串

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI 密鑰

DBEPLOCGEIEOCV-WSBQPABSSA-N

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應用

Finasteride has been used:
  • as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues[1]
  • in culture medium to treat tumor cells in vitro[2]
  • as a positive control to treat benign prostatic hyperplasia (BPH)[3]
  • to examine its effect on structural and molecular biology on the ventral prostate of senile mice[4]

生化/生理作用

选择性 5α-还原酶抑制剂;抗雄激素。
Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT.[5] It is usually used to manage benign prostate hyperplasia and pattern hair loss in male.[6] Finasteride possesses androgen-distracting properties.[1]

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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Vincent Joseph et al.
Experimental physiology, 103(2), 276-290 (2017-11-24)
What is the central question of this study? What are the contributions of allopregnanolone, the neuroactive metabolite of progesterone, and nuclear (nPR) and membrane (mPR) progesterone receptors to the respiratory effect of progesterone in newborn rats? What is the main
Finasteride adverse effects: An update
Carreno-Orellana N, et al.
Revista Brasileira de Farmacognosia, 144(12), 1584-1590 (2016)
Steven T Bird et al.
The Journal of urology, 190(5), 1811-1814 (2013-05-15)
We examined the association between 5α-reductase inhibitors and male breast cancer. Study participants were men 40 to 85 years old, with prescription and medical coverage, enrolled in the United States IMS LifeLink™ Health Plan claims database between 2001 and 2009.
Douglas J Fort et al.
Journal of applied toxicology : JAT, 39(7), 1066-1078 (2019-03-09)
The impact of the perfluoro-chemical, perfluorooctanesulfonate (PFOS), on gonadal steroidogenesis during sexual differentiation in Silurana tropicalis was examined because of its ubiquity in the environment, bioaccumulative nature and potential to disturb endocrine activity. A partial life cycle study exposing S.
Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats
Jeon W Y, et al.
BMC Complementary and Alternative Medicine, 17(1), 384-384 (2017)

Questions

  1. Is this product soluble in distilled water? I need this information because I am planning a scientific experiment.

    1 answer
    1. This material is only slightly soluble in water at a reported rate of 11.7 mg/L. The solubility of this product is tested in DMSO at a minimum rate of 20 mg/mL, with most lots soluble at 40 mg/mL. Other reported solvents include chloroform, ethanol, methanol and n-propanol. Following solubilization in any of the solvents listed above, stock solutions may typically be diluted with aqueous solvents or buffers.

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