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E5007

Supelco

依托尼秦 盐酸盐

同義詞:

1-(二乙氨乙基)-2-(对乙氧基苄基)-5-硝基苯并咪唑

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About This Item

經驗公式（希爾表示法）:
C22H28N4O3 · HCl
CAS號碼:
2053-25-0
分子量：:
432.94
MDL號碼:
MFCD00274575
分類程式碼代碼:
41116107
PubChem物質ID:
329799064
NACRES:
NA.24

等級

analytical standard

藥物控制

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

clinical testing

格式

neat

SMILES 字串

Cl.CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]([O-])=O)cc1

InChI

1S/C22H28N4O3.ClH/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3;/h7-12,16H,4-6,13-15H2,1-3H3;1H

InChI 密鑰

JTBRYBUIGVMMQL-UHFFFAOYSA-N

應用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

高选择性 μ 阿片受体激动剂。据报道，在受体结合研究和行为研究中，效果是吗啡的 100-1000 倍。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301,H336

危險分類

Acute Tox. 3 Oral - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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T May et al.
Neuroscience letters, 275(2), 109-112 (1999-11-24)
Rats, for 8 weeks consuming the mu-opioid agonist etonitazene (forced and free choice conditions yielding high and low drug-consumers), were sacrificed after 2 days or 6 weeks lasting drug deprivation. Binding characteristics of membranes from the parieto-occipital cortex of these
Lionel Moulédous et al.
FEBS letters, 589(18), 2401-2408 (2015-08-01)
Many in vitro data have shown that the efficacy of several opioid drugs is correlated with differential mu-opioid (MOP) receptor phosphorylation. Label-free semiquantitative on-line nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) analyses were performed to compare the endogenous MOP receptor phosphorylation
T P Piepponen et al.
Pharmacology, biochemistry, and behavior, 63(2), 245-252 (1999-06-17)
The role of mu1-opioid receptors in the acceleration of cerebral dopaminergic transmission induced by morphine and the putative mu1-opioid agonist, etonitazene, was studied in rats by measuring the tissue levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and
G Zernig et al.
Life sciences, 57(23), 2113-2125 (1995-01-01)
In order to quantitate the extent to which opioid agonist potencies obtained in behavioral assays are determined by the apparent in vivo affinity and efficacy of the agonist, the antinociceptive effects of the mu opioid agonists morphine, fentanyl, etonitazene, and

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