推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 97 kDa
物種活性
mouse, human
技術
microarray: suitable
western blot: 1:8,000 using NIH 3T3 mouse fibroblasts cell extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAPK7(5598)
mouse ... Mapk7(23939)
一般說明
Extracellular signal-regulated kinase 5 (ERK5), also referred to as big-MAP kinase 1 (BMK1), is a protein that belongs to mitogen-activated protein kinases family and is expressed mainly in skeletal muscle, kidney, heart and placenta. ERK5 contains a distinct 400-amino acid C-terminal and loop-12 domain, which includes two proline-rich regions.
免疫原
synthetic peptide corresponding to amino acids 789-802 of human ERK5.
應用
Anti-ERK5 (big-MAPK, BMK1) an0tibody produced in rabbit has been used in immunoblotting.
生化／生理作用
Extracellular signal-regulated kinase 5 (ERK5) has a critical role in different cellular processes like differentiation, proliferation and survival. Anti-ERK5 (big-MAPK, BMK1) antibody can be used to study the differential tissue expression and intracellular localization of the MAP Kinase isoform in normal and neoplastic tissues.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
An evolutionarily conserved pathway controls proteasome homeostasis
Rousseau A and Bertolotti A
Nature, 536(7615), 184-184 (2016)
Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth
Abe MK, et al.
Molecular and Cellular Biology, 19(2), 1301-1312 (1999)
The role of ERK1, 2, and 5 in dopamine neuron survival during aging
Parmar MS, et al.
Neurobiology of Aging, 35(3), 669-679 (2014)
Rajinder S Sawhney et al.
Journal of cellular physiology, 219(1), 152-161 (2008-12-18)
In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrin-mediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when
Adrien Rousseau et al.
Nature, 536(7615), 184-189 (2016-07-28)
The proteasome is essential for the selective degradation of most cellular proteins, but how cells maintain adequate amounts of proteasome is unclear. Here we show that there is an evolutionarily conserved signalling pathway controlling proteasome homeostasis. Central to this pathway
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