E1518

Echistatin from Echis carinatus

lyophilized powder, γ-irradiated, BioXtra

• CAS號碼: 129038-42-2
• MDL號碼: MFCD00081572
• 分類程式碼代碼: 12352202
• NACRES: NA.75

屬性

• 生物源: Echis carinatus
• 品質等級: 200
• 無菌: γ-irradiated
• 產品線: BioXtra
• 化驗: >95% (SDS-PAGE)
• 形狀: lyophilized powder
• 分子量: 5.2-5.4 kDa
• 包裝: pkg of 50 μg
• 技術: cell culture | mammalian: suitable
• 溶解度: water: soluble 0.1 mg/mL, clear, colorless
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI 密鑰: XLBBKEHLEPNMMF-SSUNCQRMSA-N

描述

一般說明

Echistatin is a small peptide disintegrin that has no multiple epitopes.[1] It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).[2]

應用

Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment[3] and murine iPSC (induced pluripotent stem cell) culture.[4]

生化／生理作用

Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.

Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1).[1] Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.[2]

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable