E1408
14-3-3 Eta histidine-tagged human
recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
同義詞:
14-3-3η, 14-3-3F, 14-3-3e, MGC93547, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, YWHAH, Ywha1
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About This Item
分類程式碼代碼:
12352200
重組細胞
expressed in E. coli
化驗
≥90% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
分子量
~30 kDa (14-3-3 proteins)
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... LOC646954(646954)
生化／生理作用
14-3-3 proteins are involved in a multitude of biological processes and play a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3η binds various proteins such as the MTLX-2 transcription factor as well as the DNA binding domain of Miz1 transcription factor. 14-3-3η also binds the glucocorticoid receptor, functioning as a positive regulator in the glucocorticoid signaling pathway. 14-3-3η is expressed and regulated in nerve cells.
外觀
Supplied as a 0.2 μm filtered solution in 50 mM Tris-HCl, pH 7.6, 1 mM EDTA, 1 mM DTT, and 20% glycerol (w/v).
相關產品
產品號碼
描述
訂價
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
S J Tang et al.
The Journal of biological chemistry, 273(39), 25356-25363 (1998-09-17)
Homeodomain proteins play important roles in various developmental processes, and their functions are modulated by polypeptide cofactors. Here we report that both in vitro and in vivo, 14-3-3eta is associated with the TLX-2 homeodomain transcription factor that is required for
Yoon Suk Kim et al.
Endocrinology, 146(7), 3133-3140 (2005-03-26)
The glucocorticoid receptor (GR), a member of the nuclear receptor superfamily, mediates the effects of glucocorticoids. It is known that 14-3-3 family proteins interact with GR and regulate its transcriptional activity. They also bind to several molecules and influence many
Michael Wanzel et al.
Nature cell biology, 7(1), 30-41 (2004-12-08)
The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3eta as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3eta to Miz1 depends on phosphorylation by Akt and
José M A Moreira et al.
Molecular & cellular proteomics : MCP, 7(7), 1225-1240 (2008-04-02)
The 14-3-3 proteins constitute a family of highly conserved and broadly expressed multifunctional polypeptides that are involved in a variety of important cellular processes that include cell cycle progression, growth, differentiation, and apoptosis. Although the exact cellular function(s) of 14-3-3
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
Guri Tzivion et al.
The Journal of biological chemistry, 277(5), 3061-3064 (2001-11-16)
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