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重要文件

D8893

Sigma-Aldrich

地塞米松

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

同義詞:

(11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮, 9α-氟-16α-甲基泼尼松龙, 泼尼松龙F

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About This Item

經驗公式(希爾表示法):
C22H29FO5
CAS號碼:
分子量::
392.46
Beilstein:
2066651
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
生物源:
synthetic (organic)
形狀:
powder
化驗:
≥80% (HPLC)
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生物源

synthetic (organic)

品質等級

無菌

γ-irradiated

產品線

BioXtra

化驗

≥80% (HPLC)

形狀

powder

效力

4-500 ng/mL

技術

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

溶解度

ethanol: 1 mL/vial, clear

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI 密鑰

UREBDLICKHMUKA-CXSFZGCWSA-N

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應用

地塞米松已被用作成骨分化培养基的组成成分。[1][2][3]它还用于研究细胞凋亡、细胞信号传导通路和基因表达。

生化/生理作用

地塞米松具有免疫抑制和止吐特性。它用于治疗术后恶心呕吐(PONV)以及化疗引起的恶心呕吐(CINV)。[4]地塞米松在心脏移植、败血症、癌症等病理疾病中发挥着重要作用。它会提升热休克蛋白的水平。[5]它是一种抗炎糖皮质素,对细胞存活、细胞信号传导和基因表达具有一系列的影响。
糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。

外觀

粉末2-8 °C;按照工作液量分装后冻存,避免反复冻融

重構

要制备20 μg/ml储备液:加入1 ml无水乙醇;轻轻旋转溶解;混合时加入49 ml无菌培养基。

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析證明 (COA)

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Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications
Fernandez-Muinos T, et al.
Acta Biomaterialia, 16(5), 35-48 (2015)
C A Smith et al.
Journal of tissue engineering and regenerative medicine, 9(5), 595-604 (2014-06-20)
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Questions

1–6 of 6 Questions  
  1. What is the best way to dissolve Product D8893, Dexamethasone?

    1 answer
    1. The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

      Helpful?

  2. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    1 answer
    1. The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. How do the dexamethasone products D8893 and the D4902 compare?

    1 answer
    1. They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

      Helpful?

  5. What solution stability information do you have available for Product D8893, Dexamethasone?

    1 answer
    1. We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

      Helpful?

  6. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    1 answer
    1. The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

      Helpful?

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