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D7750

Sigma-Aldrich

2′-脱氧胞苷 5′-单磷酸

Sigma Grade, ≥95.0%

同義詞:

dCMP, 胞嘧啶脱氧核苷酸

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About This Item

經驗公式(希爾表示法):
C9H14N3O7P
CAS號碼:
分子量::
307.20
Beilstein:
41062
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic

等級

Sigma Grade

化驗

≥95.0%

形狀

powder

溶解度

1 M NH4OH: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2

InChI

1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1

InChI 密鑰

NCMVOABPESMRCP-SHYZEUOFSA-N

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相關類別

一般說明

2′-脱氧胞苷 5′-单磷酸酯是构成DNA的脱氧核苷酸的结构单元。它由通过N-β-D-糖苷键连接含氮杂环胞嘧啶而形成的2′-脱氧-β-D-呋喃核糖组成。它在C-5 处被磷酸化′。

應用

2′-脱氧胞苷5′-单磷酸酯已被用于拉曼光谱研究,以确定其拉曼总半带宽。
2'-脱氧胞苷5'-单磷酸(dCMP)利用尿苷单磷酸(UMP)/单磷酸胞苷(CMP)激酶(EC 2.7.4.4)的底物,形成dCDP,其在磷酸化为dCTP时支持DNA生物合成。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Ivan Zlatev et al.
Bioorganic & medicinal chemistry, 17(19), 7008-7014 (2009-09-01)
The replacement of the pyrophosphate moiety of 2'-deoxynucleoside triphosphates by non natural delta-dicarboxylic butyl amino acid allows incorporation of natural 2'-deoxycytidine into DNA using HIV-1 reverse transcriptase (RT) as enzyme. In contrast, the 3'-deoxycytidine analogue was not a substrate of
Susan Quinn et al.
Chemical communications (Cambridge, England), (21)(21), 2130-2132 (2007-05-24)
A strong infrared band at 1574 cm(-1) is observed following 267 nm excitation of 2'-deoxycytidine (tau = 37 +/- 4 ps) or 2'-deoxycytidine 5'-monophosphate (tau = 33 +/- 4 ps); this band is provisionally attributed to an 1n(N)pi* state and
Makusu Tsutsui et al.
Journal of the American Chemical Society, 133(23), 9124-9128 (2011-05-13)
We report label-free electrical detections of chemically modified nucleobases in a DNA using a nucleotide-sized electrode gap. We found that methyl substitution contributes to increase the tunneling conductance of deoxycytidines, which was attributed to a shift of the highest occupied
Essentials of Chemical biology (2013)
Páraic M Keane et al.
Journal of the American Chemical Society, 133(12), 4212-4215 (2011-03-10)
The role of N1-substitution in controlling the deactivation processes in photoexcited cytosine derivatives has been explored using picosecond time-resolved IR spectroscopy. The simplest N1-substituted derivative, 1-methylcytosine, exhibits relaxation dynamics similar to the cytosine nucleobase and distinct from the biologically relevant

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