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Merck
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D6140

Sigma-Aldrich

地美环素 盐酸盐

powder or crystals, suitable for cell culture

同義詞:

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

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About This Item

經驗公式（希爾表示法）:
C21H21ClN2O8 · HCl
CAS號碼:
64-73-3
分子量：:
501.31
Beilstein:
3849198
EC號碼:
200-592-2
MDL號碼:
MFCD00082371
分類程式碼代碼:
12352207
PubChem物質ID:
24278380
NACRES:
NA.75

product name

地美环素 盐酸盐, powder or crystals

化驗

89.5-102.0% anhydrous basis

形狀

powder or crystals

技術

cell culture | mammalian: suitable

溶解度

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

−20°C

SMILES 字串

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

InChI 密鑰

GVSJQNRGSCOSNJ-KBHRXELFSA-N

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相關類別

一般說明

Chemical structure: tetracycline

生化／生理作用

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析證明 (COA)

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