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D5294

Sigma-Aldrich

Dilazep dihydrochloride

powder

同義詞:

ASTA C 4898, Cormelian, N,N′-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride

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About This Item

經驗公式（希爾表示法）:
C31H44N2O10 · 2HCl
CAS號碼:
20153-98-4
分子量：:
677.61
EC號碼:
243-548-8
MDL號碼:
MFCD00133267
分類程式碼代碼:
12352200
PubChem物質ID:
24278372
NACRES:
NA.77
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

200

顏色

white

溶解度

H2O: 10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl[H].Cl[H].COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2

InChI

1S/C31H44N2O10.2ClH/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4;;/h18-21H,7-17H2,1-6H3;2*1H

InChI 密鑰

VILIWRRWAWKXRW-UHFFFAOYSA-N

基因資訊

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

一般說明

Dilazep comprises central cyclic diamine and phenyl rings connected via alkyl linkers.[1]

應用

Dilazep dihydrochloride has been used in estrogen receptor (ERα) antagonistic assay.[2] It has also been used as an equilibrative nucleoside transporter inhibitor (ENT 1 and 2) in cancer cell lines.[3]

生化／生理作用

Dilazep is a equilibrative nucleoside transporter 1 (ENTs) inhibitor.[1] It is an antianginal drug[2] and an effective coronary vasodilator.[4] Dilazep elicits anti-albuminuric effects and is an anti-platelet agent.[4] It is a potent adenosine uptake inhibitor and suppresses effects of ischemia.[5]

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
0000350686
0000350687
0000262357
0000350687
0000350686

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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2)
Playa H, et al.
Bioorganic & medicinal chemistry letters, 24(24), 5801-5804 (2014)
S M Delaney et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 568-572 (1998-05-15)
Selective inhibitors of adenosine production, degradation and transport were used to potentiate in vivo levels of adenosine and to determine the source of both basal and N-methyl-D-aspartate (NMDA)-induced increases in levels of endogenous adenosine in vivo. Male Sprague-Dawley rats receiving
H Deguchi et al.
Blood, 90(6), 2345-2356 (1997-10-06)
Dilazep, an antiplatelet agent, is generally used as an antithrombotic drug in clinical practice. Dilazep is also known to exert cytoprotective and antioxidant effects on endothelial cells. However, its effect on the endothelial or monocyte procoagulant activity is unknown. In
Daniel Krys et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13837-13851 (2019-10-12)
Elevated proliferation rates in cancer can be visualized with positron emission tomography (PET) using 3'-deoxy-3'-l-[18F]fluorothymidine ([18F]FLT). This study investigates whether [18F]FLT transport proteins are regulated through hypoxia. Expression and function of human equilibrative nucleoside transporter (hENT)-1, hENT2, and thymidine kinase
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding
Iskar M, et al.
Molecular Systems Biology, 9(1), 662-662 (2013)
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