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重要文件

D4921

Sigma-Aldrich

Destruxin A from Metarrhizium anisopliae

≥98% (HPLC)

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About This Item

經驗公式(希爾表示法):
C29H47N5O7
CAS號碼:
分子量::
577.71
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
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生物源

Metarrhizium anisopliae

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O

InChI

1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20+,21-,23-,24-/m0/s1

InChI 密鑰

XIYSEKITPHTMJT-UTJJDKHZSA-N

應用

Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus.[1] It has been used as a transport inhibitor in Drosophila melanogaster.[2]

生化/生理作用

Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response.[3] Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase.[4] It is virustatic against arboviruses.[5]

品質

Balance is other destruxins

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Xiang Meng et al.
Toxicon : official journal of the International Society on Toxinology, 58(4), 327-335 (2011-07-02)
The cytotoxicity of a destruxin A (DA) treatment of Spodoptera litura SL-1 cells was investigated. An MTT assay showed that DA was highly toxic to SL-1 cells in a concentration- and time-dependent manner. The IC(50) values of DA, after 24 h
Esau Ruiz-Sanchez et al.
Toxicon : official journal of the International Society on Toxinology, 56(6), 1043-1051 (2010-07-31)
Destruxins, a family of cyclic peptides, are produced by various species of entomopathogenic fungi. These peptides have been shown to influence calcium-dependent processes in insect cell lines and tissues, such as skeletal muscles. To better understand the mechanism of action
Kopecky, J., et al.
Comparative Biochemistry and Physiology, 103C, 23-23 (1992)
Stefan Hutwimmer et al.
Mycologia, 102(1), 1-10 (2010-02-03)
Nutritional conditions causing droplet exudation by Metarhizium anisopliae var. anisopliae were studied. Exudation in droplets occurred only on media with more than one carbon source and was highly dependent on the ratio of a well metabolized sugar such as trehalose
Patrícia Silva Gôlo et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 20(4), 338-341 (2011-12-15)
This study evaluated the effects of destruxin A on Rhipicephalus (Boophilus) microplus females, since this toxin is one of the likely causes of high mortality induced by the entomopathogenic fungus Metarhizium anisopliae in arthropods. Ticks were immersed or inoculated with

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