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D1944

Sigma-Aldrich

D4476

≥98% (HPLC), solid

同義詞:

4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

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About This Item

經驗公式（希爾表示法）:
C23H18N4O3
CAS號碼:
301836-43-1
分子量：:
398.41
MDL號碼:
MFCD28391149
分類程式碼代碼:
12352200
PubChem物質ID:
329798715
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

solid

顏色

light yellow

溶解度

DMSO: ~20 mg/mL
H2O: insoluble

起源

GlaxoSmithKline

儲存溫度

2-8°C

SMILES 字串

NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4

InChI

1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)

InChI 密鑰

DPDZHVCKYBCJHW-UHFFFAOYSA-N

應用

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.[1][2][3]

生化／生理作用

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
D4476 may prevent or enhance apoptosis.[4] It triggers tumor suppressor p53 and impairs transcription factor E2F-1.[5]

特點和優勢

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number
0000173382
0000176977
0000176976
042M4613V
018K46095

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Serine 235 is the primary NS5A hyperphosphorylation site responsible for hepatitis C virus replication
Hsu SC, et al.
Journal of Virology, 91(14), e00194-e00117 (2017)
Yuliya V Katlinskaya et al.
Molecular and cellular biology, 36(7), 1124-1135 (2016-01-27)
Wnt pathway-driven proliferation and renewal of the intestinal epithelium must be tightly controlled to prevent development of cancer and barrier dysfunction. Although type I interferons (IFN) produced in the gut under the influence of microbiota are known for their antiproliferative
CK1alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
Cai J, et al.
Nature Cell Biology, 20(4), 465-465 (2018)
Debapriya Bhattacharya et al.
The Journal of biological chemistry, 289(23), 16508-16515 (2014-04-09)
Tuberculosis remains the biggest infectious threat to humanity with one-third of the population infected and 1.4 million deaths and 8.7 million new cases annually. Current tuberculosis therapy is lengthy and consists of multiple antimicrobials, which causes poor compliance and high
Wei Yang et al.
Cell research, 27(12), 1466-1484 (2017-10-24)
Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development. Disruption of PCP leads to severe morphological defects in vertebrates and its dysregulation results
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