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重要文件

D0444

Sigma-Aldrich

DT-2 三氟乙酸盐

≥95% (HPLC), film

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About This Item

經驗公式(希爾表示法):
C122H223N53O23 · xC2HF3O2
分子量::
2800.42 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77
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品質等級

化驗

≥95% (HPLC)

形狀

film

成份

Peptide content, ≥60%

顏色

colorless to white

溶解度

H2O: 0.5 mg/mL, clear

運輸包裝

wet ice

儲存溫度

−20°C

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-NH2

生化/生理作用

Cell permeable cGMP protein kinase (PKG) inhibitor

特點和優勢

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Mark S Taylor et al.
Molecular pharmacology, 65(5), 1111-1119 (2004-04-23)
Cyclic GMP-dependent protein kinase (PKG) serves as an important physiological regulator of vascular reactivity and tone. However, available inhibitors of PKG have exhibited variable effects in intact tissue, hindering the elucidation of the functional role of PKG in blood vessels.
Christin Christensen et al.
Stem cells and development, 15(5), 647-654 (2006-11-16)
Previously, we have shown that increasing the intracellular cGMP concentration enhances the sonic hedgehog (Shh) response in neural plate cells. The use of two mouse embryonic stem (ES) cell lines allowed a highly sensitive and reproducible quantification of the Shh
W R Dostmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14772-14777 (2000-12-20)
Arrays of octameric peptide libraries on cellulose paper were screened by using (32)P-autophosphorylated cGMP-dependent protein kinase Ialpha (cGPK) to identify peptide sequences with high binding affinity for cGPK. Iterative deconvolution of every amino acid position in the peptides identified the

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