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Key Documents

D033

Sigma-Aldrich

(+)-布他拉莫 盐酸盐

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About This Item

經驗公式(希爾表示法):
C25H31NO · HCl
CAS號碼:
分子量::
397.98
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

形狀

powder

品質等級

光學活性

[α]27/D +222° in methanol(lit.)

儲存條件

desiccated

顏色

white

溶解度

DMSO: >10 mg/mL, clear

SMILES 字串

Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C

InChI

1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1

InChI 密鑰

QZRUMKUMFJJARD-AAJWHBHYSA-N

應用

(+)-布他拉莫盐酸盐已被用作多巴胺受体阻滞剂,用于:
  • 大脑解剖切片
  • 帕金森′病标本纹状体
  • 人胚胎肾细胞(HEK293 cells)
  • 小鼠纹状体组织

生化/生理作用

(+)-布他拉莫是多巴胺受体拮抗剂,同时也是一种活性对映体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Miriam E Bocarsly et al.
Cell reports, 29(5), 1147-1163 (2019-10-31)
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate
Shoma Sato et al.
The Journal of physiology, 596(12), 2447-2461 (2018-04-17)
Synaptic potentiation in Drosophila is observed at cholinergic synapses between antennal lobe (AL) and mushroom body (MB) neurons in the adult brain; however, depression at the AL-MB synapses has not yet been identified. By ex vivo Ca2+ imaging in an
Seeman
Pharmacological Reviews, 32, 229-229 (1981)
P J Pauwels et al.
British journal of pharmacology, 134(1), 88-97 (2001-08-28)
1. Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recombinant human
Kimberly Regna et al.
BMC developmental biology, 16(1), 15-15 (2016-05-18)
Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. Multiple factors exist that

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