跳轉至內容
Merck
全部照片(1)

文件

C6303

Sigma-Aldrich

钙磷蛋白C 来源于枝孢样枝孢霉

≥90% (HPLC), powder

同義詞:

UCN-1028c

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C44H38O14
CAS號碼:
分子量::
790.76
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

microbial (Cladosporium cladosporioides)

品質等級

化驗

≥90% (HPLC)

形狀

powder

顏色

red to brown

溶解度

DMF: 1 mg/mL
DMSO: 1 mg/mL
ethanol: 1 mg/mL

儲存溫度

−20°C

SMILES 字串

COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24

InChI

1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3

InChI 密鑰

SRJYZPCBWDVSGO-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

生化/生理作用

高度特异性的蛋白激酶C抑制剂(IC50 = 50 nM); 需要光才能激活。研究显示,在较高浓度(100 nM或更高)下,它在体外可抑制细胞增殖并诱导细胞凋亡。

特點和優勢

《受体分类和信号转导》手册的 磷脂酶DPKC 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

客戶也查看了

I Ozaki et al.
The Journal of biological chemistry, 274(9), 5310-5317 (1999-02-20)
Apoptosis was induced in human glioma cell lines by exposure to 100 nM calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of caspase-3
E Kobayashi et al.
Biochemical and biophysical research communications, 159(2), 548-553 (1989-03-15)
Calphostin C (UCN-1028C), a newly isolated compound from Cladosporium cladosporioides, is a potent and specific inhibitor of protein kinase C, because it was 1000 times more inhibitory to protein kinase C (IC50, 0.05 microM) than other protein kinases such as
H Ikemoto et al.
Journal of neurosurgery, 83(6), 1008-1016 (1995-12-01)
Calphostin C acts at the regulatory domain as a highly selective inhibitor of protein kinase C (PKC), and staurosporine acts at the catalytic domain as a nonspecific PKC inhibitor. The authors investigated the capacity of calphostin C and staurosporine to
Yang Chen et al.
Annals of translational medicine, 10(3), 132-132 (2022-03-15)
The currently available treatment methods are ineffective in reducing mortality or improving outcomes in acute lung injury (ALI). The activation of protein kinase C alpha (PKCα) has recently been implicated in ALI development. We explored the potential therapeutic outcomes of
M Begemann et al.
Anticancer research, 18(5A), 3139-3152 (1998-12-22)
Protein kinase C (PKC) is a central component in signal transduction and growth control and might be an appropriate target for the chemotherapy of human brain tumors. This study demonstrates that the staurosporine derivative Ro 31-8220, a potent PKC inhibitor

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務