C6223

Monoclonal Anti-CXCR-1 (IL-8 RA) antibody produced in mouse

clone 42705.111, purified immunoglobulin, lyophilized powder

• MDL號碼: MFCD02096157
• 分類程式碼代碼: 51111800
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 42705.111, monoclonal
• 形狀: lyophilized powder
• 物種活性: human
• 技術: flow cytometry: 10 μg/mL using using human blood cells (10 μL diluted antibody/10⁵-10⁶ cells); immunohistochemistry (frozen sections): 25 μg/mL using human tissue (speen); neutralization: suitable
• 同型: IgG2a
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... IL8RA(3577) ; mouse ... Il8ra(227288)

描述

一般說明

Chemokine receptor CXCR1 also refers as type I IL-8 receptor or IL-8RA is a class A, rhodopsin-like G-protein-coupled receptor, expressed mainly in neutrophils but not in T or B lymphocytes . It has a crucial role in cellular signal transduction and targeted as drug receptors. Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used to neutralize the bioactivity facilitated by human cell surface CXCR-1. Mouse anti-CXCR-1 (IL-8 RA) antibody reacts specifically with CXCR-1 transfected cells but not with the parent cell line. The product has also shown no cross-reactivity with human CXCR-2.

特異性

The antiboody, in the presence of anti-CXCR2 (Sigma Product No. C6348), will neutralize human cell surface CXCR-1 mediated-myloperoxidase release from human granulocytes induced by IL-8. The antibody reacts with human CXCR1 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR2.

免疫原

human CXCR1 transfected NSO mouse myeloma cells.

應用

Monoclonal anti-CXCR-1 (IL-8 RA) antibody can be used in flow cytometry for detecting CXCR-1 present on human blood cells. It can also be used in immunohistochemistry (25 μg/mL) using frozen human tissue sections (spleen).

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

準備報告

Purified using protein G.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable