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C5423

Sigma-Aldrich

克仑特罗 盐酸盐

≥95% (TLC), powder, β2-adrenoceptor agonist

同義詞:

4-氨基-& # 945;-(叔丁基氨基甲基)-3,5-二氯苄醇 盐酸盐

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About This Item

經驗公式(希爾表示法):
C12H18Cl2N2O · HCl
CAS號碼:
分子量::
313.65
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

product name

克仑特罗 盐酸盐, ≥95%

化驗

≥95%

形狀

powder

drug control

Home Office Schedule 4.2

儲存溫度

2-8°C

SMILES 字串

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI 密鑰

OPXKTCUYRHXSBK-UHFFFAOYSA-N

基因資訊

human ... ADRB2(154)

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應用

盐酸克伦特罗已被用作:
  • 来自鸡骨骼肌的 β-肾上腺素能受体(β -AR)的激动剂,以诱导大鼠
  • 的咬肌、二腹肌和颞肌中的肥大效应。
  • 作为串联质谱(MS-MS)中的参照β-激动剂标准

生化/生理作用

盐酸克伦特罗是一种& # 946;2-肾上腺素受体激动剂和支气管扩张剂。它能有效改善哮喘患者的呼气峰流速(PEFR)。克伦特罗也是一种提高性能的药物,因为它刺激中枢神经系统并改善氧转运。克伦特罗在扩张型心肌病患者中引发心脏保护功能。

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Carc. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Vipin Arora et al.
Molecular pain, 17, 1744806921997206-1744806921997206 (2021-04-09)
Beta 2 adrenergic receptor (β2 AR) activation in the central and peripheral nervous system has been implicated in nociceptive processing in acute and chronic pain settings with anti-inflammatory and anti-allodynic effects of β2-AR mimetics reported in several pain states. In
beta2-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats
Zhang Q, et al.
British Journal of Pharmacology, 160(6), 1561-1572 (2010)
H M Zuurmond et al.
Molecular pharmacology, 56(5), 909-916 (1999-10-26)
Previously, we demonstrated the involvement of Asn293 in helix VI of the human beta(2)-adrenergic receptor in stereoselective agonist recognition and activation. In the present study, we have further explored the role of this residue by synthesizing derivatives of isoproterenol and
beta1-and beta2-adrenergic receptor stimulation differ in their effects on PGC-1alpha and atrogin-1/MAFbx gene expression in chick skeletal muscle
Shimamoto S, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 211, 1-6 (2017)
Effects of clenbuterol, a beta2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles
Ishikawa C, et al.
The Open Dentistry Journal, 3, 191-191 (2009)

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