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Merck
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重要文件

C3909

Sigma-Aldrich

D-环丝氨酸

synthetic

同義詞:

(R)-4-氨基-3-异噁唑烷酮, 4-氨基-3-异噁唑烷酮

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About This Item

經驗公式(希爾表示法):
C3H6N2O2
CAS號碼:
分子量::
102.09
Beilstein:
80798
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.28

生物源

synthetic

品質等級

形狀

powder

mp

147 °C (dec.) (lit.)

溶解度

water: 50 mg/mL, clear, colorless to light yellow

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

作用方式

cell wall synthesis | interferes

儲存溫度

−20°C

SMILES 字串

N[C@@H]1CONC1=O

InChI

1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1

InChI 密鑰

DYDCUQKUCUHJBH-UWTATZPHSA-N

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一般說明

Chemical structure: amino acid derivatives

應用

D-cycloserine has been used to inhibit serine hydroxymethyltransferase.

生化/生理作用

作用方式:抑制细胞壁生物合成(D-Ala 肽键形成)。同时可防止将D-Ala转化为L-Ala。抑菌性。
作用于 NMDA 谷氨酸能受体的甘氨酸调节位点的部分激动剂;抗革兰氏阴性细菌的抗生素。
干预方式:D-Ala转运干预。

其他說明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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L-serine treatment may improve neurorestoration of rats after permanent focal cerebral ischemia potentially through improvement of neurorepair
Sun L, et al.
PLoS ONE, 9(3), e93405-e93405 (2014)
Rick Richardson et al.
Learning & memory (Cold Spring Harbor, N.Y.), 11(5), 510-516 (2004-10-07)
Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of
Stefan G Hofmann et al.
The American journal of psychiatry, 170(7), 751-758 (2013-04-20)
The authors examined whether D-cycloserine, a partial agonist at the glutamatergic N-methyl-d-aspartate receptor, augments and accelerates a full course of comprehensive cognitive-behavioral therapy (CBT) in adults with generalized social anxiety disorder. This was a multisite randomized placebo-controlled efficacy study with
Kathryn D Baker et al.
Learning & memory (Cold Spring Harbor, N.Y.), 19(10), 461-469 (2012-09-18)
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits, little is known about the mechanisms by which DCS promotes the loss of fear.
Bram Vervliet
Acta psychologica, 127(3), 601-613 (2007-08-21)
This review addresses the effects of the cognitive enhancer D-cycloserine (DCS) on the memory processes that occur in conditioned fear extinction, which is the experimental model for exposure techniques to reduce clinical anxiety. All reported rat studies show an enhanced

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