化驗
>94%
形狀
solid
光學活性
[α]22/D −95.9°, c = 1.1 in H2O(lit.)
藥物控制
USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada
顏色
white
溶解度
H2O: soluble
ethanol: soluble
儲存溫度
−20°C
SMILES 字串
OC(C(O)C(O)=O)C(O)=O.COC(=O)[C@@H]1C2CCC(C[C@@H]1c3ccccc3)N2C
InChI
1S/C16H21NO2.C4H6O6/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11;5-1(3(7)8)2(6)4(9)10/h3-7,12-15H,8-10H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t12-,13+,14+,15-;/m0./s1
InChI 密鑰
WYGLYLVLBCZESH-PEVLCXCCSA-N
生化／生理作用
Binds to the cocaine receptor site on the dopamine transporter and blocks dopamine uptake.
特點和優勢
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
注意
吸湿
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Emily M Jutkiewicz et al.
Annals of emergency medicine, 54(3), 409-420 (2008-11-18)
Cocaine toxicity results in cardiovascular complications, seizures, and death and accounts for approximately 20% of drug-related emergency department visits every year. Presently, there are no treatments to eliminate the toxic effects of cocaine. The present study hypothesizes that a bacterial
M E Reith
European journal of pharmacology, 130(1-2), 65-72 (1986-10-14)
Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine
J D Steketee
Behavioural brain research, 97(1-2), 39-48 (1998-12-29)
A role for the mesolimbic dopamine system in the development of behavioral sensitization to psychostimulants, such as cocaine and amphetamine, is well established. Previous reports have suggested that the ventral tegmental area (VTA) is involved in the initiation of, while
Saturable (3H)cocaine binding in central nervous system of mouse.
M E Reith et al.
Life sciences, 27(12), 1055-1062 (1980-09-22)
A Brouard et al.
Brain research. Developmental brain research, 75(1), 13-17 (1993-09-17)
The cellular localization of the cocaine binding sites in primary cultures of embryonic rat mesencephalic cells was previously reported to differ from that observed in adult rat brain. In order to know whether this different localization was associated with a
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