C1240
Chlormethiazole hydrochloride
≥98% (HPLC), powder
同義詞:
4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride
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About This Item
經驗公式（希爾表示法）:
C6H8ClNS · HCl
CAS號碼:
分子量：:
198.11
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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描述
Store desiccated
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white
溶解度
H2O: soluble >10 mg/mL
起源
AstraZeneca
SMILES 字串
Cl.Cc1ncsc1CCCl
InChI
1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
InChI 密鑰
OFXYKSLKNMTBHK-UHFFFAOYSA-N
生化／生理作用
Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus.[1] Long term administration of chlormethiazole leads to addiction to the drug.[2]
GABAA agonist; glycine receptor modulator.
特點和優勢
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
Koichi Nisijima et al.
Neurochemistry international, 43(2), 155-164 (2003-03-07)
The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg)
A Nurse's Survival Guide to Acute Medical Emergencies (2011)
Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)
Rachel C Knopp et al.
Redox biology, 32, 101486-101486 (2020-03-11)
Oxidative stress induced by lipid peroxidation products (LPP) accompanies aging and has been hypothesized to exacerbate the secondary cascade in traumatic brain injury (TBI). Increased oxidative stress is a contributor to loss of neural reserve that defines the ability to
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DISCOVER Bioactive Small Molecules for Neuroscience
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