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About This Item
經驗公式（希爾表示法）:
C30H43FN4O11
CAS號碼:
分子量：:
654.68
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況
推薦產品
生物源
synthetic (organic)
品質等級
化驗
≥90% (TLC)
形狀
powder
溶解度
methanol: 10 mg/mL
DMSO: 20 mM, clear, colorless to light yellow
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
InChI
1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
InChI 密鑰
CTXDBLYOEUERAT-VUVYEONESA-N
Amino Acid Sequence
Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK
應用
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
- to study the activity of caspase-8 in porcine kidney cells[1]
- to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells[2]
- to study its effects on retinal ganglion and astroglia in rat eyes[3]
生化／生理作用
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.[4]
特點和優勢
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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