These measurements are two different values and not equivalent. Note that this product is offered at 1.5 - 2.0 units/mg solid. The mass quantity per vial, based on the activity specification, will be 7.5 - 10 mg/vial. This unit per milligram activity is reported on the lot specific Certificate of Analysis. Please see the link below to review a sample Certificate:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/B8416-15UNSLCL5046.pdf
推薦產品
產品名稱
硫酸博来霉素 来源于轮枝链霉菌, 1.5-2.0 units/mg solid, BioReagent, suitable for cell culture
產品線
BioReagent
品質等級
形狀
powder or crystals
比活性
1.5-2.0 units/mg solid
技術
cell culture | mammalian: suitable
顏色
white to off-white
溶解度
H2O: 20 mg/mL, clear, colorless
抗生素活性譜
fungi
作用方式
DNA synthesis | interferes
儲存溫度
2-8°C
SMILES 字串
[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C
InChI
1S/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1
InChI 密鑰
OOXTWFJZZAJGKA-CNLAFNBISA-N
尋找類似的產品？ 前往 產品比較指南
一般說明
Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Chemical structure: glycopeptide
應用
Bleomycin is used in combination with Etoposide and Cisplatin to treat testicular, ovarian and cervical cancer. This combination is popular as BEP chemotherapy and has also been demonstrated as effective and most successful chemotherapy regimen in germ-cell tumors. Since it is a cytotoxic agent, bleomycin is known to induce endothelial damage the lung vasculature referred to as bleomycin-induced lung-injury or bleomycin-induced pneumonitis (BIP). Researchers have used this property of bleomycin to induce lung fibrosis in mouse and rat models.
生化／生理作用
Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
成分
This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.
注意
This product should be stored at 2-8°C.
準備報告
The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
其他說明
Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic
訊號詞
Danger
危險聲明
危險分類
Carc. 2 - Muta. 1B - Repr. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
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文章
Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
抗生素致死曲線是一種劑量反應實驗，哺乳類動物細胞在選擇抗生素時，其劑量會不斷增加。
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Is 15 unit of bleomycin is the same as 15 mg of bleomycin
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