B3436

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

≥98% (HPLC), solid

• 同義詞: C2-8
• 經驗公式（希爾表示法）: C₁₉H₁₄Br₂N₂O₃S
• CAS號碼: 300670-16-0
• 分子量：: 510.20
• MDL號碼: MFCD00355835
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724418
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: off-white
• 溶解度: DMSO: ~20 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1
• InChI: 1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)
• InChI 密鑰: SJJKUNDBFWUAQB-UHFFFAOYSA-N

描述

生化／生理作用

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl] benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin).

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319,H413
• 防範說明: P273 - P305 + P351 + P338
• 危險分類: Aquatic Chronic 4 - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves