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933554

Sigma-Aldrich

NanoFabTx™ NTA Lipid Mix

for synthesis of NTA-functionalized liposomes for small molecule delivery

同義詞:

Cholesterol, DGS-NTA(Ni), HSPC, PEG-DSPE

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About This Item

分類程式碼代碼:
12352211
NACRES:
NA.21

品質等級

100

儲存溫度

−20°C

應用

NanoFabTx™ NTA Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of NTA-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with NTA groups using extrusion and microfluidics are also included. The synthesized NTA-functionalized liposomes enable the conjugation of His-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.

特點和優勢

  • A ready-to-use nanoformulation lipid blend for the synthesis of NTA-functionalized liposomes
  • Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
  • Flexible synthesis methods to create uniform and reproducible liposomes
  • Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
  • Lipid mix optimized for His-tagged protein or antibody conjugation and small molecule encapsulation
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

法律資訊

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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分析證明 (COA)

Lot/Batch Number
MKCV0300

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Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids
Torre, Paola, et al.
Proceedings of the National Academy of Sciences (2019)
Mitsuru Ando et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(10), 1800524-1800524 (2018-10-26)
Integral membrane proteins (IMPs) modulate key cellular processes; their dysfunctions are closely related to disease. However, production of IMPs in active conformations for further study is hindered by aggregation and toxicity in living expression systems. IMPs are therefore produced in
Mesoscale active matter in fluids
Klotsa, Daphne
Soft Matter (2019)
Zhilin Chen et al.
Bioconjugate chemistry, 29(4), 1251-1260 (2018-03-13)
The number and spacing of B-cell epitopes on antigens have a profound impact on the activation of B cells and elicitation of antibody responses, the quantitative aspects of which may be utilized for rational design of vaccines. Ni-chelating liposomes have

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