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重要文件

A9855

Sigma-Aldrich

3-乙酰基-11-酮-β-乳香酸

from Boswellia serrata

同義詞:

AKBA

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About This Item

經驗公式（希爾表示法）:
C32H48O5
CAS號碼:
67416-61-9
分子量：:
512.72
MDL號碼:
MFCD03788777
分類程式碼代碼:
12352106
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

Boswellia serrata

形狀

powder

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

SMILES 字串

O([C@H]1[C@]([C@H]2[C@@]([C@@H]3[C@]([C@@]4(CC[C@@]5([C@@H]([C@H]([C@@H](CC5)C)C)C4=CC3=O)C)C)(CC2)C)(CC1)C)(C)C(=O)O)C(=O)C

InChI

1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1

InChI 密鑰

HMMGKOVEOFBCAU-BCDBGHSCSA-N

相關類別

一般說明

乙酰基-11-酮基-β-乳香酸（AKBA）是从 齿叶乳香树脂中提取的。[1]

應用

3-乙酰基-11-酮基-β-乳香酸（AKBA）已被用于：
  • 在体外模型中测试其作为抗增殖剂与伊马替尼联用对肝星状细胞 （HSC） 增殖和协同作用的影响[2]
  • 研究其对雌性 Sprague Dawley 大鼠卵巢切除引起的骨质疏松症的抗骨质疏松作用[3]
  • 在一项与阿司匹林的比较研究中测试其作为抗炎药在 APCMin/+ 小鼠中预防肠腺瘤性息肉病的作用[4]

生化／生理作用

乙酰基-11-酮基-β-乳香酸是一种五环三萜，它能以选择性、酶定向、非氧化还原和非竞争性方式抑制5-脂氧合酶。它还可以抑制拓扑异构酶I和NF-κB 信号传导。
乙酰基-11-酮基-β-乳香酸（AKBA）分别对表皮葡萄球菌和 金黄色葡萄球菌有抗菌和抗生物膜活性。[5]它是核因子E2 相关因子(Nrf2)的激活剂， 在体外和体内研究中具有针对缺血性损伤的神经保护特性。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000407710
0000407710
0000404077
0000381227
0000374545

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Alsaba F Raja et al.
BMC microbiology, 11, 54-54 (2011-03-17)
Boswellic acids are pentacyclic triterpenes, which are produced in plants belonging to the genus Boswellia. Boswellic acids appear in the resin exudates of the plant and it makes up 25-35% of the resin. β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid
Mona Abdel-Tawab et al.
Clinical pharmacokinetics, 50(6), 349-369 (2011-05-11)
Non-steroidal anti-inflammatory drug (NSAID) intake is associated with high prevalence of gastrointestinal or cardiovascular adverse effects. All efforts to develop NSAIDs that spare the gastrointestinal tract and the cardiovasculature are still far from achieving a breakthrough. In the last two
Elena Tibaldi et al.
Biochimica et biophysica acta, 1843(2), 288-298 (2013-10-22)
The dimerization and auto-transphosphorylation of platelet-derived growth factor receptor (PDGFR) upon engagement by platelet-derived growth factor (PDGF) activates signals promoting the mitogenic response of hepatic stellate cells (HSCs) due to liver injury, thus contributing to the development of hepatic fibrosis.
Ruiqi Wang et al.
Drug discoveries & therapeutics, 8(1), 25-32 (2014-03-22)
Acetyl-11-keto-beta-BA (AKBA), a component of the gum resin of Boswellia serrata, has been recognized as a promising agent for the prevention of intestinal tumorigenesis. Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has also been considered to have the activity against intestinal
Yi Ding et al.
Scientific reports, 4, 7002-7002 (2014-11-12)
Stroke is a complex disease involved oxidative stress-related pathways in its pathogenesis. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. Acetyl-11-Keto-β-Boswellic Acid (AKBA) is an active triterpenoid compound
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