跳轉至內容
Merck
全部照片(1)

重要文件

查看所有文件

A9393

Sigma-Aldrich

氨苄西林

anhydrous, 96.0-102.0% (anhydrous basis)

同義詞:

D-(−)-α-氨苄青霉素

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C16H19N3O4S
CAS號碼:
69-53-4
分子量：:
349.40
Beilstein:
1090925
EC號碼:
200-709-7
MDL號碼:
MFCD00005175
分類程式碼代碼:
51281703
PubChem物質ID:
24891442
NACRES:
NA.85
暫時無法取得訂價和供貨情況

品質等級

200

化驗

96.0-102.0% (anhydrous basis)

形狀

solid

pKa (25 °C)

2.5 (COOH)
7.3 (NH2)

mp

208 °C (dec.) (lit.)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3)C(O)=O

InChI

1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1

InChI 密鑰

AVKUERGKIZMTKX-NJBDSQKTSA-N

尋找類似的產品？ 前往 產品比較指南

相關類別

一般說明

化学结构:β-内酰胺

應用

氨苄西林已被用于研究抗生素的耐药性和渗透性限制、多种抗生素之间的协同作用、某些血液感染，并已被用于开发检测脑脊液耐药基因的 PCR 检测法。[1][2][3][4]

生化／生理作用

ββ-内酰胺被 β-内酰胺酶灭活，因此氨苄青霉素与 β-内酰胺酶抑制剂一起使用。[5][6][7]
作用机制：氨苄西林是一种半合成的青霉素和ß-内酰胺抗生素，其通过灭活位于细菌的细胞膜内表面的转肽酶从而抑制细菌细胞壁合成。

耐药性机制：ß-内酰胺酶切开氨苄青霉素的ß-内酰胺环,使其失去活性。

抗菌谱：对革兰氏阳性菌（类似于苄青霉素）和革兰氏阴性菌（类似于四环素和氯霉素）均有效。

注意

据报道，该产品在25°C、43%和81%相对湿度下可稳定6周。 另外的研究表明氨苄青霉素在溶液中的稳定性与pH、温度和缓冲液的性质有关。 当储存在 pH 值 7 以上时，它′的活性很快就会丧失。 推荐最佳保存条件为2-8℃，pH 3.8-5，一周内其活性可保留90%。

準備報告

据报道，氨苄青霉素微溶于水，几乎不溶于酒精、氯仿、醚和固定油脂，但溶于稀酸或稀碱。 该溶液不应高压灭菌;原液应通过过滤消毒并冷冻保存，可稳定数月。

其他說明

在氩气环境中储存。保存于密闭容器内，置于干燥通风处，吸湿性。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H317,H334

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000377945
0000365017
0000348054
0000307889
0000365017

未看到正確版本？

如果您需要一個特定的版本，您可以透過批號來尋找特定憑證。

搜尋 COA

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases.
Antimicrobial Agents and Chemotherapy, 29, 955-957 (1986)
M R Jacobs et al.
Antimicrobial agents and chemotherapy, 29(6), 980-985 (1986-06-01)
The in vitro synergistic activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam, combined with ampicillin, ticarcillin, mezlocillin, azlocillin, piperacillin, and apalcillin, were determined against 34 strains of members of the Enterobacteriaceae family, Pseudomonas aeruginosa, Aeromonas hydrophila, and Haemophilus
J N Anderl et al.
Antimicrobial agents and chemotherapy, 44(7), 1818-1824 (2000-06-20)
The penetration of two antibiotics, ampicillin and ciprofloxacin, through biofilms developed in an in vitro model system was investigated. The susceptibilities of biofilms and corresponding freely suspended bacteria to killing by the antibiotics were also measured. Biofilms of Klebsiella pneumoniae
Laurent Poirel et al.
Antimicrobial agents and chemotherapy, 52(5), 1613-1617 (2008-02-27)
The basis of the beta-lactam resistance of 39 multidrug-resistant Acinetobacter baumannii isolates recovered from hospitalized patients was studied. These isolates were collected from 2001 to 2005 at the Sahloul Hospital in Sousse, Tunisia. They belonged to two distinct clones. One
Kenneth H Rand et al.
The Journal of antimicrobial chemotherapy, 53(3), 530-532 (2004-02-14)
We used a novel screening method to look for synergy between daptomycin and 18 other antibiotics against 19 strains of high-level vancomycin-resistant enterococci (VRE) (vancomycin MIC > or = 256 mg/L). In this approach, daptomycin was incorporated into Ca(2+)-supplemented Mueller-Hinton
查看所有相關論文

Questions

1–7 of 7 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. Which Ampicillin product has higher water solubility, Product A9393 or Product A9518?

    1 answer

    1. Product No. A9518 (Ampicillin, sodium salt) is soluble at 50 mg/mL in water.

      Helpful?

  5. How do I use Ampicllin in agar plates?

    1 answer

    1. For plates, add ampicillin to autoclaved media cooled to 48°C, to a final concentration of 35-50 μg/mL. Pour the plates, and allow them to cool completely. Plates may be stored at 2-8°C for up to only 1-2 weeks before use.

      Helpful?

  6. Is Ampicillin product stable in solution?

    1 answer

    1. We recommend using freshly prepared solutions. A concentrated solution of sodium ampicillin in water (approximately 330 mg/mL) may be expected to lose about 10% potency in 20 hours at -20°C.

      Helpful?

  7. What is the solubility of Product A9393, Ampicillin?

    1 answer

    1. The solubility of ampicillin is tested at 50 mg/mL in 1M ammonium hydroxide. Additional solubility information can be found on the product information sheet (under Documents, above).

      Helpful?

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務