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Merck
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A8185

Sigma-Aldrich

丙氨酸-谷氨酰胺

BioReagent, suitable for cell culture, suitable for insect cell culture

同義詞:

丙氨酰谷氨酰胺, 丙谷二肽

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About This Item

經驗公式（希爾表示法）:
C8H15N3O4
CAS號碼:
39537-23-0
分子量：:
217.22
MDL號碼:
MFCD00133046
分類程式碼代碼:
12352209
PubChem物質ID:
24891211
NACRES:
NA.75

產品線

BioReagent

品質等級

300

化驗

≥98% (HPLC)

形狀

powder

技術

cell culture | insect: suitable
cell culture | mammalian: suitable

顏色

white to off-white

儲存溫度

room temp

SMILES 字串

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI 密鑰

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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相關類別

應用

丙氨酰谷氨酰胺可用于：
  • 用作NeuralQ™培养基的补充剂
  • 用作视网膜细胞系生长培养基和培育培养基(IM)的组分
  • 分别应用于视网膜细胞系的实验性治疗

生化／生理作用

丙氨酰谷氨酰胺(Ala-Gln)是一种在哺乳动物细胞培养基中用于替代谷氨酰胺的二肽，因为溶液中谷氨酰胺的不稳定性和分解产物氨的形成可对培养细胞产生有害影响。丙氨酰谷氨酰胺对热力灭菌稳定，比谷氨酰胺具有更低的氨化性，有助于发挥其作为培养基成分的优势。利用丙氨酰谷氨酰胺研究体外多形核白细胞和髓过氧化物酶的活性。

分析報告

该产品经过细胞培养测试（0.5mg/ml）和昆虫细胞培养测试（0.2mg/ml）。它适用于2-10mM的细胞培养和昆虫细胞培养应用。

法律資訊

NeuralQ is a trademark of GlobalStem

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Vinicius Fernandes Cruzat et al.
Nutrition (Burbank, Los Angeles County, Calif.), 25(4), 428-435 (2008-12-06)
We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations of glutamine, glutamate, and glutathione (GSH) in rats subjected to long-duration
Vinicius Fernandes Cruzat et al.
Cell biochemistry and function, 28(1), 24-30 (2009-11-04)
In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted
The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium
Christie A, et al.
Biotechnology and Bioengineering, 64(3), 298-309 (1999)
A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics
Alterman JF, et al.
Bio-protocol, 7(16) (2017)
T Hassell et al.
Applied biochemistry and biotechnology, 30(1), 29-41 (1991-07-01)
Eight independent cell lines accumulated ammonia in culture to concentrations between 1.3 and 2.9 mM. The growth inhibition of such concentrations of ammonium chloride when added to culture medium was variable. The cell lines tested could be divided into 3
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