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About This Item
經驗公式（希爾表示法）:
C28H28N2 · 2HCl
CAS號碼:
分子量：:
465.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
暫時無法取得訂價和供貨情況
化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
顏色
white to off-white
溶解度
DMSO: ≥5 mg/mL
儲存溫度
−20°C
SMILES 字串
Cl[H].Cl[H].C(CNC(c1ccccc1)c2ccccc2)NC(c3ccccc3)c4ccccc4
InChI
1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChI 密鑰
YRQCDCNQANSUPB-UHFFFAOYSA-N
應用
AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.
生化／生理作用
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC50 = 64 nM) and stimulates GTPγS binding (EC50 = 290 nM) similar to L-AP4 and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 stimulates the release of stress hormones (corticosterone and ACTH), orally active and brain penetrable.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Katharina Gryksa et al.
Genes, brain, and behavior, 19(1), e12627-e12627 (2019-12-04)
The group III metabotropic glutamate receptor subtype 7 (mGlu7) is an important regulator of glutamatergic and GABAergic neurotransmission and known to mediate emotionality and male social behavior. However, a possible regulatory role in maternal behavior remains unknown to date. Adequate
Karolina Podkowa et al.
Neuropharmacology, 141, 214-222 (2018-08-27)
Scopolamine, a muscarinic cholinergic receptor antagonist, exerts fast and prolonged antidepressant effects in the clinic. In contrast, the current treatments for major depressive disorder (MDD) require long-term drug administration. On the other hand, the sole use of scopolamine might be
Stefania Risso Bradley et al.
Pharmacology, biochemistry, and behavior, 101(1), 35-40 (2011-12-06)
Currently prescribed antidepressants affect the reuptake and/or metabolism of biogenic amines. Unfortunately for patients, these treatments require several weeks to produce significant symptom remission. However, recently it has been found that ketamine, a dissociative anesthetic agent that noncompetitively antagonizes NMDA
Tomoteru Yamasaki et al.
EJNMMI research, 3(1), 54-54 (2013-07-23)
Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant KB = 30 nM), and evaluated
Katarzyna Stachowicz et al.
Neuroscience letters, 741, 135435-135435 (2020-11-11)
Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus
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