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Merck
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文件

A3734

Sigma-Aldrich

1-氮杂坎帕罗酮

≥97% (HPLC)

同義詞:

9-溴-7,12-二氢-吡啶并[3′,2′:2,3]吖庚因并[4,5-b]吲哚-6(5H)-酮

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About This Item

經驗公式(希爾表示法):
C15H10BrN3O
CAS號碼:
分子量::
328.16
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥97% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

gray-brown

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1

InChI

1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)

InChI 密鑰

NTSBZVCEIVPKBJ-UHFFFAOYSA-N

生化/生理作用

1-Azakenpaullone 是一种细胞渗透性、有效的选择性糖原合酶激酶 3 抑制剂3β (GSK3β)与 CDK 的交叉反应性低 100 倍。1-Azakenpaullone 可与 BIO 和 CHIR99021 一起用作 GSK3 抑制的“金标准”。
1-氮杂坎帕罗酮(AZP)可刺激β-连环蛋白相关基因的转录。该化合物能诱导β细胞的增殖和复制。

注意

空气敏感

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Rong Hu et al.
Stem cells translational medicine, 6(1), 121-130 (2017-02-09)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome.
Combination effects of AHR agonists and Wnt beta-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions
Wincent E, et al.
Toxicology and Applied Pharmacology, 284(2), 163-179 (2015)
9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication
Stukenbrock H, et al.
Journal of medicinal chemistry, 51(7), 2196-2207 (2008)
Thiranut Jaroonwitchawan et al.
Biochemical and biophysical research communications, 481(1-2), 176-181 (2016-11-07)
Neural crest (NC) is a transient population, arising during embryonic development and capable of differentiating into various somatic cells. The defects of neural crest development leads to neurocristopathy. Several signaling pathways were revealed their significance in NC cell specification. Fibroblast
Jens H Fritzenwanker et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(17), 8403-8408 (2019-04-11)
The trunk is a key feature of the bilaterian body plan. Despite spectacular morphological diversity in bilaterian trunk anatomies, most insights into trunk development are from segmented taxa, namely arthropods and chordates. Mechanisms of posterior axis elongation (PAE) and segmentation

文章

糖原合酶激酶 3 (GSK-3) 是許多通路中 100 多種蛋白質的高度保守的丝氨酸/苏氨酸激酶家族。請參閱已接受的 GSK-3 調製劑及相關產品清單。

Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.

We offer many products related to PKB/Akt for your research needs.

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