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A2754

Sigma-Aldrich

腺苷-5'-二磷酸 钠盐

bacterial, ≥95% (HPLC)

同義詞:

ADP钠盐, ADP

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About This Item

經驗公式（希爾表示法）:
C10H15N5O10P2
CAS號碼:
20398-34-9
分子量：:
427.20
分類程式碼代碼:
41106305
eCl@ss:
32160414
PubChem物質ID:
24890690
NACRES:
NA.51
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生物源

bacterial

品質等級

300

化驗

≥95% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI 密鑰

XTWYTFMLZFPYCI-KQYNXXCUSA-N

基因資訊

human ... HSP90AA1(3320) , P2RY1(5028)

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相關類別

一般說明

5′-二磷酸腺苷（ADP）是一种通过 FOF1-ATP 合酶转化为 ATP 而参与能量储存和核酸代谢的腺嘌呤核苷酸。ADP也可通过单磷酸腺苷酸（AMP）的腺苷酸激酶催化反应得到。ADP是一种血小板激动剂，由血小板致密颗粒分泌。它通过其与ADP受体P2Y1和P2Y12的相互作用影响血小板活化。ADP在通过ecto-ADP酶转化为腺苷后，通过腺苷受体抑制血小板活化。

應用

5′-二磷酸腺苷钠盐已用作：
  • 血小板聚集的阳性对照，用聚焦仪分析纯化解聚素的抗血小板活性。
  • 制备原液以进行线粒体应激实验。
  • 流式细胞术分析中的阳性对照品，用于研究五聚体C反应蛋白（pCRP）和单体CRP（mCRP）对血小板CD62p（P-选择素）表达的影响。
  • 血小板激动剂，刺激血小板聚集。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

nwg

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
0000406586
0000394607
0000394608
0000392901
0000392902

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Given the rising incidence of non-alcoholic fatty liver disease (NAFLD) in both adults and children, the development of a non-invasive diagnostic method for assessing disease progression to non-alcoholic steatohepatitis (NASH) has become an important research goal. Currently available non-invasive imaging
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Bone fracture repair is a multifaceted, coordinated physiological process that requires new bone formation and resorption, eventually returning the fractured bone to its original state. Currently, a variety of different approaches are pursued to accelerate the repair of defective bones
Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo
Jin RC, et al.
Circulation, 123(18), 1963-1973 (2011)
Klaus H Nielsen et al.
RNA (New York, N.Y.), 15(1), 67-75 (2008-11-27)
The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion
Richard C Jin et al.
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Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke
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LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Questions

1–6 of 6 Questions  

  1. Is product A2754 FDA approved for use in testing patient samples (Platelet aggregation/function testing) at this time?

    1 answer

    1. No, the product A2754 is not FDA approved for testing patient samples for platelet aggregation/function testing at this time.

      Helpful?

  2. I see that the  molecular weight for Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754, on the website does not include sodium, water and solvent content. Why is that?

    1 answer

    1. The amount of sodium, water and solvent for ADP sodium salt will vary from lot to lot.  The specific lot information can be found on the certificate of analysis located at our website. To obtain the "true" molecular weight (so that one can calculate the molarity of a solution), the sodium, water and solvent amount must be added to the molecular weight listed on the website.

      Helpful?

  3. What are the spectral properties of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. The millimolar extinction coefficient of a pH 7 solution of ADP sodium salt is 15.4 at the absorbance maximum wavelength of 259 nm.

      Helpful?

  4. What is the solubility of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. ADP sodium salt is soluble in water at a concentration of 50 mg/mL.

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  5. What is the solution stability of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. ADP sodium salt is stable in solution for several months when stored at pH 7 and at -20 °C.  When a solution is stored at pH 7 and 4 °C, the solution is stable for several days. It is unstable in acid.

      Helpful?

  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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