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Merck
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重要文件

A2731

Sigma-Aldrich

AMG 9810

≥98% (HPLC), powder

同義詞:

2E-N-(2,3-二氢-1,4-苯并二恶英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺

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About This Item

經驗公式(希爾表示法):
C21H23NO3
CAS號碼:
分子量::
337.41
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: >5 mg/mL

起源

Amgen

儲存溫度

2-8°C

SMILES 字串

CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

InChI

1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+

InChI 密鑰

GZTFUVZVLYUPRG-IZZDOVSWSA-N

生化/生理作用

AMG 9810是TRPV1受体的有效非香草醛拮抗剂。IC50 = 17 nM。
AMG 9810是一种肉桂酰胺TRPV1(类香草醇受体1)拮抗剂,在辣椒碱刺激的动物模型中,可以防止由辣椒素刺激的擦眼行为,并且可以逆转痛觉过敏。它具有抗痛觉过敏特性。[1]

特點和優勢

该化合物由Amgen开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 4

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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