推薦產品
生物源
bovine articular cartilage
品質等級
形狀
lyophilized powder
包裝
glass bottle of 1 mg
技術
cell culture | mammalian: suitable
雜質
salt, essentially free
顏色
white
溶解度
H2O: 2 mg/mL
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
cow ... AGC1(280985)
應用
聚集蛋白聚糖是软骨结构和关节功能的关键成分。 研究人员正在研究其合成和降解，以了解其在关节损伤疾病和衰老过程中软骨退化中的作用。
生化／生理作用
这种分子产生一种刚性、可逆、耐压缩的可变形凝胶。 它与透明质酸结合形成非常大的大分子复合物，该复合物具有增加的流体动力学体积和显著增加的溶液相对粘度（30-40%）。
成分
聚集蛋白聚糖是软骨细胞外基质的主要结构蛋白聚糖。 它是一种大蛋白聚糖，分子量大于 2,500 kDa，由连接核心蛋白的大约 100-150 条氨基聚糖链组成。 这些氨基聚糖链大多为软骨素/硫酸皮肤素。聚集蛋白聚糖包含G1、G2 和 G3三个球状结构域，它们与聚集和透明质素（hylauronan ）结合、细胞粘附和软骨细胞凋亡有关。
注意
在 -20°C 储存。按供货时的状态储存，如果储存得当，这种粉末在 3 年内几乎没有分解。
準備報告
该产品从关节软骨中提取，经过化学纯化、水透析，并在冻干前无菌过滤。 一旦冻干，这种粉末基本上不含盐。 产品在水中的溶解度为 2 mg/mL。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
L Cao et al.
Experimental cell research, 246(2), 527-537 (1999-02-02)
A major feature of cartilage deterioration during joint injury and disease is aggrecan degradation and the loss of proteoglycan. Most of the degraded fragments are released into the circulatory system except the G1 domain which accumulates locally in the synovial
The structure, function and turnover of aggrecan, the large aggregating proteoglycan from cartilage.
T E Hardingham et al.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 32(4), 249-257 (1994-04-01)
Aggrecan, the large aggregating proteoglycan from cartilage contains chondroitin sulphate and keratan sulphate attached to a multidomain protein core. It aggregates by binding to hyaluronan and this is further stabilised by a separate globular link protein. There are two structurally
N Ishiguro et al.
Arthritis and rheumatism, 42(1), 129-136 (1999-01-27)
To determine the relationship between matrix metalloproteinases (MMPs), their inhibitors, and the turnover of matrix molecules in articular cartilage from patients with osteoarthritis (OA). Synovial fluid samples were collected from the knees of 54 patients with OA. Radiographic evaluations and
Association of the aggrecan keratan sulfate-rich region with collagen in bovine articular cartilage.
H Hedlund et al.
The Journal of biological chemistry, 274(9), 5777-5781 (1999-02-20)
Aggrecan, the predominant large proteoglycan of cartilage, is a multidomain macromolecule with each domain contributing specific functional properties. One of the domains contains the majority of the keratan sulfate (KS) chain substituents and a protein segment with a proline-rich hexapeptide
L Cao et al.
Matrix biology : journal of the International Society for Matrix Biology, 17(5), 379-392 (1998-11-20)
The proteoglycan aggrecan is a major component of cartilage, and degradation of aggrecan is associated with aging and a number of pathological conditions. To investigate the effects of the accumulation of G1 domain from degraded aggrecan, we overexpressed the G1
文章
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
瞭解更多關於糖胺聚醣和蛋白質聚醣的資訊，包括糖胺聚醣 (GAG) 的結構、不同類型的 GAG 及其功能。
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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