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來源證明/COA

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A002

N⁶-Cyclohexyladenosine

Name: N<SUP>6</SUP>-Cyclohexyladenosine
Brand: SIGMA

同義詞:

CHA

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About This Item

經驗公式（希爾表示法）:

C₁₆H₂₃N₅O₄

CAS號碼:

36396-99-3

分子量：:

349.38

MDL號碼:

MFCD00036808

分類程式碼代碼:

12352204

PubChem物質ID:

329770564

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SMILES 字串

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCCC4)ncnc23

InChI

1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1

InChI 密鑰

SZBULDQSDUXAPJ-XNIJJKJLSA-N

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一般說明

N^6-Cyclohexyladenosine belongs to the class of new generation thermolytic agents.[1]

生化／生理作用

N⁶-Cyclohexyladenosine is an adenosine A1 receptor agonist.[2] It prevents thermogenesis and other response such as shivering in response to cold. N⁶-Cyclohexyladenosine initiates hibernation in animals.[1]

取代透過

產品號碼

描述

訂價

C9901

N⁶-Cyclohexyladenosine

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析證明 (COA)

Lot/Batch Number

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Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine

Crosson CE, et al.

Investigative Ophthalmology & Visual Science, 46(10), 3795-3799 (2005)

Precise Control of Target Temperature Using N6-Cyclohexyladenosine and Real-Time Control of Surface Temperature

Laughlin BW, et al.

Therapeutic hypothermia and temperature management, 8(2), 108-116 (2018)

Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons.

Matthew Edward Pamenter et al.

Brain research, 1213, 27-34 (2008-05-06)

Adenosine is a defensive metabolite that is critical to anoxic neuronal survival in the freshwater turtle. Channel arrest of the N-methyl-d-aspartate receptor (NMDAR) is a hallmark of the turtle's remarkable anoxia tolerance and adenosine A1 receptor (A1R)-mediated depression of normoxic

Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.

Gerard J Marek

Neuropharmacology, 56(8), 1082-1087 (2009-03-28)

Modulation of glutamatergic neurotransmission by metabotropic glutamate2/3 (mGlu2/3) receptor agonists effectively treats seemingly diverse neuropsychiatric illness such as generalized anxiety disorder and schizophrenia. Activation of adenosine A(1) heteroceptors, like mGlu2 autoreceptors, decreases glutamate release in the medial prefrontal cortex (mPFC)

Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.

Domenico Tupone et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(36), 14512-14525 (2013-09-06)

Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the induction of the hypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for the A1AR agonist N6-cyclohexyladenosine to induce a hypothermic, torpor-like state

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