η(6)-对伞花烃钌(II)配合物对模拟癌症和健康细胞膜的Langmuir单分子膜的影响与其毒性无关。:该研究探讨了η(6)-对伞花烃钌(II)复合物对模拟癌症和健康细胞膜的Langmuir单分子膜(包括1,2-二棕榈酰-sn-甘油-3-磷酸胆碱(DPPC))的影响,揭示了膜相互作用和细胞毒性机制(Wrobel et al., 2024)。
L-苯丙氨酸与混合脂膜中羰基的相互作用。:该研究探讨了L-苯丙氨酸与混合脂膜(含有 DPPC)中羰基的相互作用,以了解氨基酸在膜动力学和稳定性中的作用(Brandan et al., 2024)。
存在脂质筏时布洛芬药物在模型膜中的空间排列。:该研究调查了以DPPC为成分时,布洛芬在含有脂质筏的模型膜中的空间排列,揭示了药物与膜的相互作用以及脂质筏在药物输送中的作用(Kashnik et al., 2024)。
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause