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Merck
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86305

Sigma-Aldrich

互变霉素 来源于螺旋轮丝链霉菌

≥90% (HPLC)

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About This Item

經驗公式（希爾表示法）:
C41H66O13
CAS號碼:
109946-35-2
分子量：:
766.95
Beilstein:
3583132
分類程式碼代碼:
12352200
PubChem物質ID:
329769454
NACRES:
NA.25

生物源

Streptomyces spiroverticillatus

化驗

≥90% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

CO[C@@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)C1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(C)=O)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@@H](O)C3=C(C)C(=O)OC3=O)C(C)C

InChI

1S/C41H66O13/c1-21(2)36(51-34(47)20-31(45)35-27(8)39(48)52-40(35)49)38(50-10)32(46)19-30(44)26(7)29(43)13-11-24(5)37-25(6)16-18-41(54-37)17-15-23(4)33(53-41)14-12-22(3)28(9)42/h21-26,29,31-33,36-38,43,45-46H,11-20H2,1-10H3/t22-,23+,24+,25-,26-,29-,31+,32+,33-,36+,37-,38-,41+/m0/s1

InChI 密鑰

RFCWHQNNCOJYTR-QKIDKDKQSA-N

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應用

Tautomycin from Streptomyces spiroverticillatus may be used to study its potential as an anti-fungal and anticancer agent. Tautomycin may be used as a potent and specific protein phosphatase inhibitor.

其他說明

Potent and specific inhibitor of protein phosphatases 1 and 2A

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

防範說明

P264 - P301 + P310

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析證明 (COA)

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Magne O Sydnes et al.
Chemistry, an Asian journal, 5(3), 410-420 (2009-12-17)
It has been a long journey since tautomycin (TTM) was isolated in 1987 and the discovery that it inhibited protein phosphatase 1 (PP1) more strongly than PP2A until finally the cocrystal structure of TTM and PP1 was presented early in
Jianhua Ju et al.
Organic letters, 11(7), 1639-1642 (2009-03-14)
The biosynthetic gene cluster for tautomycin (TTM), a potent protein phosphatase (PP) inhibitor has recently been characterized. Inactivation of ttmM, which encodes a putative C3' hydroxylase, afforded mutant SB6005 which accumulated three new 3'-deshydroxy TTM analogs, supporting the function of
C MacKintosh et al.
FEBS letters, 277(1-2), 137-140 (1990-12-17)
Tautomycin inhibited the catalytic subunits of protein phosphatase-1 (Kiapp = 0.16 nM) more potently than protein phosphatase 2A (Kiapp = 0.4 nM), and the native forms of these enzymes in mammalian, protozoan and plant extracts were inhibited in a similar
Magne O Sydnes et al.
Bioorganic & medicinal chemistry, 16(4), 1747-1755 (2007-12-07)
Herein we describe the further improvement of our in-house developed firefly bioluminescence assay system for the determination of inhibition of protein phosphatase (PP). The advantage with the new system is higher sensitivity as well as being time and sample efficient.
Wenli Li et al.
Journal of natural products, 72(3), 450-459 (2009-02-05)
Tautomycetin (TTN) is a highly potent and specific protein phosphatase inhibitor isolated from Streptomyces griseochromogenes. The biological activity of TTN makes it an important lead for drug discovery, whereas its rare dialkylmaleic anhydride moiety and structural similarity to tautomycin (TTM)
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