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79710

Sigma-Aldrich

O-磷酸-DL-丝氨酸

≥98.0% (NT), suitable for cell culture

同義詞:

DL-2-氨基-3-羟基丙酸3-磷酸, DL-SOP, DL-丝氨酸单磷酸

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About This Item

經驗公式(希爾表示法):
C3H8NO6P
CAS號碼:
分子量::
185.07
Beilstein:
1726828
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
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產品名稱

O-磷酸-DL-丝氨酸, ≥98.0% (NT)

化驗

≥98.0% (NT)

形狀

powder or crystals

技術

cell culture | mammalian: suitable

雜質

≤0.5% free serine (TLC)
≤1% water

顏色

white to faint beige

SMILES 字串

NC(COP(O)(O)=O)C(O)=O

InChI

1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)

InChI 密鑰

BZQFBWGGLXLEPQ-UHFFFAOYSA-N

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生化/生理作用

O-磷酸-DL-丝氨酸(pSer)用于研究非酶性氨基磷脂糖基化。
O-磷酸丝氨酸可用于通过O-磷酰基-tRNA:硒代半胱氨酰-tRNA合酶(SepSecS)催化的O-磷酸丝氨酸(Sep)的tRNA依赖性转化进行半胱氨酸和硒代半胱氨酸(Sec)的生物合成的替代途径中。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Yoko Chiba et al.
The Journal of biological chemistry, 288(16), 11448-11458 (2013-03-13)
Novel-type serine-synthesizing enzymes, termed metal-independent phosphoserine phosphatases (iPSPs), were recently identified and characterized from Hydrogenobacter thermophilus, a chemolithoautotrophic bacterium belonging to the order Aquificales. iPSPs are cofactor-dependent phosphoglycerate mutase (dPGM)-like phosphatases that have significant amino acid sequence similarity to dPGMs
Yuhei Araiso et al.
Nucleic acids research, 36(4), 1187-1199 (2007-12-26)
The micronutrient selenium is present in proteins as selenocysteine (Sec). In eukaryotes and archaea, Sec is formed in a tRNA-dependent conversion of O-phosphoserine (Sep) by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SepSecS). Here, we present the crystal structure of Methanococcus maripaludis SepSecS complexed with
Seong-Jun Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6413-6418 (2014-04-16)
Mitochondrial dynamics is crucial for the regulation of cell homeostasis. Our recent findings suggest that hepatitis C virus (HCV) promotes Parkin-mediated elimination of damaged mitochondria (mitophagy). Here we show that HCV perturbs mitochondrial dynamics by promoting mitochondrial fission followed by
Anselm Sauerwald et al.
Science (New York, N.Y.), 307(5717), 1969-1972 (2005-03-26)
Several methanogenic archaea lack cysteinyl-transfer RNA (tRNA) synthetase (CysRS), the essential enzyme that provides Cys-tRNA(Cys) for translation in most organisms. Partial purification of the corresponding activity from Methanocaldococcus jannaschii indicated that tRNA(Cys) becomes acylated with O-phosphoserine (Sep) but not with
Guillermo N Armaiz-Pena et al.
Nature communications, 4, 1403-1403 (2013-01-31)
Noradrenaline can modulate multiple cellular functions important for cancer progression; however, how this single extracellular signal regulates such a broad array of cellular processes is unknown. Here we identify Src as a key regulator of phosphoproteomic signalling networks activated in

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