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重要文件

76157

Sigma-Aldrich

(4R)-4-羟基-L-谷氨酸

≥98.0% (TLC)

同義詞:

erythro-(4R)-4-Hydroxy-L-glutamic acid, H-(2S,4R)-γ-Hydroxy-Glu-OH

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About This Item

經驗公式(希爾表示法):
C5H9NO5
CAS號碼:
分子量::
163.13
Beilstein:
1725871
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.28
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產品名稱

(4R)-4-羟基-L-谷氨酸, ≥98.0% (TLC)

化驗

≥98.0% (TLC)

形狀

powder

光學活性

[α]/D 20.5±1.5°, c = 1 in H2O

顏色

white

mp

171 °C

儲存溫度

−20°C

SMILES 字串

N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

InChI

1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

InChI 密鑰

HBDWQSHEVMSFGY-STHAYSLISA-N

生化/生理作用

(4R)-4-Hydroxy-L-glutamic acid or (2S,4R)-4-hydroxyglutamate was shown to activate the metabotropic glutamate receptors, mGlu1a, mGlu2, and mGlu8a in a dose-dependent manner. [1]
Substrate for aminotransferase[2]; pharmacological characterization at human glutamate transporter subtypes 1-3[3]; for studying structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors[4].

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
A GOLDSTONE et al.
The Journal of biological chemistry, 237, 3476-3485 (1962-11-01)
Lennart Bunch et al.
ChemMedChem, 4(11), 1925-1929 (2009-09-05)
Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether
A S Bessis et al.
Bioorganic & medicinal chemistry letters, 11(12), 1569-1572 (2001-06-20)
The (2S,4R)- and (2S,4S)-4-hydroxyglutamates activate cloned mGlu(1a), mGlu(2), and mGlu(8a) receptors with different potencies. Best results were obtained with the (2S,4S) isomer being almost as potent as glutamate on mGlu(1a)R and mGlu(8a)R. Data are interpreted on the basis of the
Sebastien Alaux et al.
Journal of medicinal chemistry, 48(25), 7980-7992 (2005-12-13)
A series of nine L-2,4-syn-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized

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