74675

新生霉素 钠盐

≥93% (HPLC)

• 同義詞: Albamycin, Cathomycin, Novobiocin, Novobiocin, Monosodium Salt
• 經驗公式（希爾表示法）: C₃₁H₃₅N₂NaO₁₁
• CAS號碼: 1476-53-5
• 分子量：: 634.61
• Beilstein: 3892910
• EC號碼: 216-023-6
• 分類程式碼代碼: 51101500
• NACRES: NA.85

屬性

• 化驗: ≥93% (HPLC)
• 形狀: powder
• 光學活性: [α]20/D −48±3°, c = 1% in ethanol
• 顏色: white to faint beige
• 溶解度: H₂O: soluble
• 抗生素活性譜: Gram-positive bacteria
• 作用方式: DNA synthesis | interferes; enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: [Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C
• InChI: 1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1
• InChI 密鑰: AXOUUAINTJNFRS-UHFFFAOYSA-N

描述

一般說明

Chemical structure: coumarin-glycoside

應用

Novobiocin is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA. It is an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. It also is an inhibitor of retrovirus RNA-dependent DNA-polymerase.

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

生化／生理作用

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitors of the ATPase reaction catalysed by GyrB . It is also a Hsp90 inhibitor . Antimicrobial spectrum: Gram-positive bacterial.

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

包裝

1g, 5g

其他說明

Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Store under inert gas. Keep in a dry place.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H317,H319
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves