全部照片(1)
About This Item
經驗公式（希爾表示法）:
C11H20N2O8
CAS號碼:
分子量：:
308.29
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32
推薦產品
![Fmoc-Ser[GalNAc(Ac)3-α-D]-OH 95%](/deepweb/assets/sigmaaldrich/product/structures/252/386/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a/640/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a.png)
![Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 97%](/deepweb/assets/sigmaaldrich/product/structures/250/325/42734f24-7836-4aaa-ba6a-6284bf7e8181/640/42734f24-7836-4aaa-ba6a-6284bf7e8181.png)
product name
Tn Antigen, ≥99.0% (TLC)
化驗
≥99.0% (TLC)
形狀
powder or crystals
儲存溫度
−20°C
SMILES 字串
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI 密鑰
REDMNGDGDYFZRE-WKWISIMFSA-N
相關類別
一般說明
Tn 抗原是一种截短的 O -聚糖，在结直肠癌（CRC）中常见。通常在癌细胞中高水平表达。Tn 抗原体积小，结构简单。其在人体内具有非生理性聚糖结构，因此可能被免疫系统识别为异物。
生化／生理作用
Tn 抗原通过 H-Ras 介导的上皮间质转换刺激结直肠癌转移。作为几种重要复合物 O -聚糖的前体。携带 Tn 抗原的所有谱系中的血细胞亚群导致一种称为 Tn 综合征的血液疾病。
包裝
无底玻璃瓶。内含物装在插入式熔锥内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Yasuyuki Matsumoto et al.
Glycobiology, 30(5), 282-300 (2019-11-20)
The Tn antigen is a neoantigen abnormally expressed in many human carcinomas and expression correlates with metastasis and poor survival. To explore its biomarker potential, new antibodies are needed that specifically recognize this antigen in tumors. Here we generated two
Xichen Dong et al.
BioMed research international, 2018, 9532389-9532389 (2018-07-24)
Immature truncated O-glycans such as Tn antigen are frequently detected in human colorectal cancer (CRC); however, the precise pathological consequences of Tn antigen expression on CRC are unknown. T-synthase is the key enzyme required for biosynthesis of mature O-glycans. Here
Neha M Sahasrabudhe et al.
Biological chemistry, 399(7), 649-659 (2018-06-13)
Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a major ligand for the C-type lectin macrophage galactose-type lectin (MGL).
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation
Liu Z, et al.
Journal of Cellular and Molecular Medicine (2019)
Brian R Stotter et al.
American journal of physiology. Renal physiology, 318(2), F518-F530 (2020-01-07)
Mucin-type O-linked glycosylation, a posttranslational modification affecting the stability and biophysical characteristics of proteins, requires C1GalT1 (T synthase) and its obligate, X-linked chaperone Cosmc. Hypomorphic C1GalT1 mutations cause renal failure via not yet established mechanisms. We hypothesize that impaired Cosmc-dependent
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務