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50847

Sigma-Aldrich

Gramicidin C from Bacillus brevis

~90% (HPLC)

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About This Item

CAS號碼:
分類程式碼代碼:
51283112
NACRES:
NA.85

生物源

Bacillus brevis

化驗

~90% (HPLC)

形狀

powder

雜質

≤5% water

顏色

white to off-white

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell membrane | interferes
enzyme | inhibits

儲存溫度

2-8°C

SMILES 字串

CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(=O)[C@@H]4CCCN4C(=O)[C@@H](Cc5ccccc5)NC1=O)C(C)C)C(C)C

一般說明

Chemical structure: peptide

應用

Gramicidin is a naturally occuring polypeptide antibiotic. It functions as a transmembrane ion channel and is used for studies on phospholipid bilayer membrane fluidity measured by lateral diffusion.

生化/生理作用

Gramicidin′s bactericidal activity is a result of increasing the permeability of the bacterial cell membrane. This allows inorganic monovalent cations to travel through unrestricted which thereby destroys the ion gradient between the cytoplasm and the extracellular environment .
Naturally occuring polypeptide antibiotic with Tyr at position 11; functions as a transmembrane ion channel.

包裝

10mg

其他說明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. Keep in a dry place.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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G.A. Brewer
Anal. Profiles Drug Subst., 8, 179-179 (1979)
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases.
Francisco J. Alvarez-Leefmans; Eric Delpire
Physiology and Pathology of Chloride Transporters and Channels in the Nervous System: From Molecules to Diseases, 142-142 (2009)
Dong Hyeon Lee et al.
Yonsei medical journal, 49(3), 459-471 (2008-06-27)
This study examined the expression and function of inward rectifier K(+) channels in cultured rat hepatic stellate cells (HSC). The expression of inward rectifier K(+) channels was measured using real-time RT-PCR, and electrophysiological properties were determined using the gramicidin-perforated patch-clamp

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