N1271

甲基盐霉素 来源于Streptomyces auriofaciens

≥98% (HPLC)

• 同義詞: 4-methylsalinomycin, Monteban, narasin A
• 經驗公式（希爾表示法）: C₄₃H₇₂O₁₁
• CAS號碼: 55134-13-9
• 分子量：: 765.03
• MDL號碼: MFCD00133653
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24897476
• NACRES: NA.85

屬性

• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 溶解度: methanol: soluble 20 mg/mL
• 抗生素活性譜: Gram-positive bacteria; fungi; viruses
• 作用方式: cell membrane | interferes
• 儲存溫度: −20°C
• SMILES 字串: CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O
• InChI: 1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)
• InChI 密鑰: VHKXXVVRRDYCIK-UHFFFAOYSA-N

描述

應用

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

生化／生理作用

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na⁺, K⁺, and H⁺ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H⁺ concentration on the inside of the Gram-positive cell. Therefore, the H⁺ ATPase pump is activated to transport out excess H⁺. The cell is depleted of its energy resources and reduces fermentative functions and cell division .

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges