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Merck
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重要文件

466R-1

Sigma-Aldrich

SDHB (EP288) Rabbit Monoclonal Primary Antibody

同義詞:

Succinate dehydrogenase B

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About This Item

分類程式碼代碼:
12352203
暫時無法取得訂價和供貨情況

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP288, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (466R-14)
vial of 0.1 mL concentrate Research Use Only (466R-14-RUO)
vial of 0.5 mL concentrate (466R-15)
vial of 1.0 mL concentrate (466R-16)
vial of 1.0 mL concentrate Research Use Only (466R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (466R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (466R-17)
vial of 7.0 mL pre-dilute ready-to-use (466R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (466R-18-RUO)

製造商／商標名

Cell Marque®

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

GIST

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic

基因資訊

human ... SDHB(6390)

相關類別

一般說明

Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane.[1][2] Many cancers are generally positive for SDHB, including renal cell carcinomas (RCC) and gastrointestinal stromal tumors (GIST). However, a subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.[3][4]

品質


IVD
IVD
IVD
RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律資訊

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
0000418433
0000418433
0000411268
0000411268
0000411270

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H C Au et al.
Gene, 159(2), 249-253 (1995-07-04)
The iron-sulfur protein (Ip) subunit of succinate dehydrogenase (SDH and complex II) of the respiratory chain is highly conserved in evolution [Gould et al., Proc. Natl. Acad. Sci. USA 86 (1989) 1934-1938]. We have cloned the entire human Ip cDNA
Sean R Williamson et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(1), 80-94 (2014-07-19)
Patients with germline mutation of succinate dehydrogenase (SDH) subunit genes are prone to develop paraganglioma, gastrointestinal stromal tumor, and rarely renal cell carcinoma (RCC). However, SDH-deficient RCC is not yet widely recognized. We identified such tumors by distinctive morphology and
Anthony J Gill et al.
Human pathology, 41(6), 805-814 (2010-03-20)
Up to 30% of pheochromocytomas and paragangliomas are associated with germline RET, Von Hippel-Lindau (VHL), neurofibromatosis type I (NF1), and succinate dehydrogenase subunits (SDHB, SDHC, and SDHD) mutations. Genetic testing allows familial counseling and identifies subjects at high risk of
José Gaal et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(1), 147-151 (2010-10-05)
Mutations in the tumor suppressor genes SDHB, SDHC, and SDHD (or collectively SDHx) cause the inherited paraganglioma syndromes, characterized by pheochromocytomas and paragangliomas. However, other tumors have been associated with SDHx mutations, such as gastrointestinal stromal tumors (GISTs) specifically in

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